User:Owenwilborn/Choose an Article

Article Selection
All five articles below are rated as Mid-Importance and Stub-Class by WikiProject Molecular and Cell Biology.

Option 1

 * Article title: Mature messenger RNA
 * Article Evaluation
 * Mature mRNA is important in eukaryotic cells because mature mRNA does not contain any introns and only contains exons, the part of the genetic code that is translated to form proteins . Despite the importance of processing mRNA between transcription and translation the article does not contain any organization, sources, or discussion about mRNA regulation, application, and importance and can be greatly improved upon.
 * Mature mRNA is important in eukaryotic cells because mature mRNA does not contain any introns and only contains exons, the part of the genetic code that is translated to form proteins . Despite the importance of processing mRNA between transcription and translation the article does not contain any organization, sources, or discussion about mRNA regulation, application, and importance and can be greatly improved upon.


 * Sources
 * Some sources which could be a starting point to improve the article are:
 * RNA Splicing by the Spliceosome - https://pubmed.ncbi.nlm.nih.gov/31794245/
 * More than a messenger: Alternative splicing as a therapeutic target - https://pubmed.ncbi.nlm.nih.gov/31271898/
 * More than a messenger: Alternative splicing as a therapeutic target - https://pubmed.ncbi.nlm.nih.gov/31271898/

Option 2

 * Article title Adaptive enzyme
 * Article Evaluation
 * Adaptive enzymes (Inducible enzymes) are enzymes not normally present in the cell until a specific condition, such as a drop in oxygen concentration in the cell, is meet, resulting in activation of transcription and formation of that enzyme . Inducible enzymes are important because regulating transcription under induced conditions is a potential medical application . However, this article has no sources and only beefily describes how the inducing agent turns on gene transcription with one example given.
 * Adaptive enzymes (Inducible enzymes) are enzymes not normally present in the cell until a specific condition, such as a drop in oxygen concentration in the cell, is meet, resulting in activation of transcription and formation of that enzyme . Inducible enzymes are important because regulating transcription under induced conditions is a potential medical application . However, this article has no sources and only beefily describes how the inducing agent turns on gene transcription with one example given.


 * Sources
 * Some sources which could be a starting point to improve the article are
 * Inducible nitric oxide synthase: Good or bad? - https://pubmed.ncbi.nlm.nih.gov/28651238/
 * Inducible nitric oxide synthase: Regulation, structure, and inhibition - https://pubmed.ncbi.nlm.nih.gov/31192483/
 * Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous? - https://pubmed.ncbi.nlm.nih.gov/31035491/
 * Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous? - https://pubmed.ncbi.nlm.nih.gov/31035491/

Option 3

 * Article title Artificial transcription factor
 * Article Evaluation
 * Artificial transcription factors bind to the DNA to positively or negatively regulate DNA transcription . Unlike natural occurring transcription factor, artificial transcription factors are synthetically designed to overcome natural transcription factor's limitations . Artificial transcription factors are an important potential medical therapy, however the current article only has 2 references and 4 lines of information.
 * Artificial transcription factors bind to the DNA to positively or negatively regulate DNA transcription . Unlike natural occurring transcription factor, artificial transcription factors are synthetically designed to overcome natural transcription factor's limitations . Artificial transcription factors are an important potential medical therapy, however the current article only has 2 references and 4 lines of information.


 * Sources
 * Some sources which could be a starting point to improve the article are:
 * Reprogramming cell fate with artificial transcription factors - https://pubmed.ncbi.nlm.nih.gov/29389011/
 * Angelman syndrome: Current and emerging therapies in 2016 - https://pubmed.ncbi.nlm.nih.gov/27860204/
 * Angelman syndrome: Current and emerging therapies in 2016 - https://pubmed.ncbi.nlm.nih.gov/27860204/

Option 4

 * Article title Solid phase sequencing
 * Article Evaluation
 * Solid phase sequencing is a DNA sequencing method where the DNA is linearized, attached to a solid support, and separated into a single strand; the single strand template is then used for DNA sequencing . Despite solid phase sequencing being developed in the late 1980's and being used in many second-generation DNA sequencing techniques the article is only a few sentences long and is missing citations.
 * Sources
 * Some sources which could be a starting point to improve the article are:
 * Direct solid phase sequencing of genomic and plasmid DNA using magnetic beads as solid support - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC318085/
 * A crash course in sequencing for a microbiologist - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373407/
 * Solid phase DNA minisequencing by an enzymatic luminometric inorganic pyrophosphate detection assay - https://pubmed.ncbi.nlm.nih.gov/8382019/
 * Solid phase DNA sequencing using the biotin-avidin system - https://academic.oup.com/nar/article-abstract/16/7/3025/1292569?redirectedFrom=fulltext
 * Solid phase DNA minisequencing by an enzymatic luminometric inorganic pyrophosphate detection assay - https://pubmed.ncbi.nlm.nih.gov/8382019/
 * Solid phase DNA sequencing using the biotin-avidin system - https://academic.oup.com/nar/article-abstract/16/7/3025/1292569?redirectedFrom=fulltext

Option 5

 * Article title Pulse labelling
 * Article Evaluation
 * Pulse labelling is a method to track a molecules movement and lifespan in a cell using radioactive material . Radioactive molecules of interest are added to to the media for a brief time period, before being replaced by identical nonradioactive molecules, by tracking the radioactive levels in the cell over time the uptake, metabolism, and transport of the molecule of interest is found . This article only contains one line and one source and can be greatly improved upon.
 * Pulse labelling is a method to track a molecules movement and lifespan in a cell using radioactive material . Radioactive molecules of interest are added to to the media for a brief time period, before being replaced by identical nonradioactive molecules, by tracking the radioactive levels in the cell over time the uptake, metabolism, and transport of the molecule of interest is found . This article only contains one line and one source and can be greatly improved upon.


 * Sources
 * Some sources which could be a starting point to improve the article are:
 * Oxford Reference - https://www.oxfordreference.com/view/10.1093/oi/authority.20110803100354495
 * RNA Methodologies (Fifth Edition) Chapter 19 - Analysis of Nuclear RNA - https://www.sciencedirect.com/science/article/pii/B9780128046784000191
 * RNA Methodologies (Fifth Edition) Chapter 19 - Analysis of Nuclear RNA - https://www.sciencedirect.com/science/article/pii/B9780128046784000191