User:PSYC458 student/sandbox

Rs6313

The T102C polymorphism has been shown to be in complete linkage disequilibrium with the rs6311 (A-1438G).

Many individual studies have been done to investigate possible effects of the rs6313 polymorphism on phenotypes such as personality traits or disorders and their endophenotypes.

The C-allele has been associated with higher extraversion personality scores among borderline personality disorder patients and the presence of visual and auditory hallucinations in patients with Late-onset Alzheimer’s Disease. Multiple studies have found that individuals with schizophrenia who are homozygous for the C-allele tend to do worse on working memory tasks than do individuals with a T-allele. Rs6313 has also been shown to be associated with novelty seeking among Italian mood disorder patients and reward dependence in a German population. The SNP may also be associated with rheumatoid arthritis. One study found no association between the SNP and suicidal behavior in a Chinese population, and anther found no association with fibromyalgia syndrome.