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Production of ARANESPTM (DARBEPOETIN ALFA)

The synthetic erythropoietin known as darbepoetin alfa is marketed under the brand name Aranesp by Amgen. The main purpose of Aranesp is to treat patients with low levels of red blood cells caused by chronic liver failure or chemotherapy treatment used in cancer. Through recombinant DNA technology, Aranesp is expressed in the genotype of Chinese hamster ovary (CHO) cells. Engineered Aranesp has a chemical structure that consists of 5 N-linked oligosaccharide chains.