User:Patelurology2/DrugIP

DrugIP ...
 * Pancreatitis


 * Pages that link to "Pancreatitis"

Structural relationships of drugs

 * Structure–activity relationship
 * Pharmacophore ,
 * Molecular Property Explorer/modeling
 * Quantitative Structure Activity Relationship (QSAR) modeling
 * Quantitative Structure Activity Relationship (QSAR) modeling


 * :Pubmed"Structure-Activity Relationship"[MeSH Terms drug induced pancreatitis ]
 * Pancreatitis SAR related citation
 * Structure-activity relationships in drug-induced pancreatic islet cell toxicity.
 * Cytosolic Double-Stranded DNA as a Damage-Associated Molecular Pattern Induces the Inflammatory Response in Rat Pancreatic Stellate Cells: A Plausible Mechanism for Tissue Injury-Associated Pancreatitis
 * Proteolysis
 * Apoptosis
 * Chymotrypsin
 * Disulfide bond
 * Valproic acid Valproic acid also blocks the voltage-gated sodium channels and T-type calcium channels.
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What links to Pancreatitis
see in edit mode

Linezolid a weak monoamine oxidase inhibitor (MAOI)

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Drug vs mechanism of pancreatitis
<!--- TABLE 3. All Medications Implicated in Pancreatitis A. Anitmicrobials 1. Antivirals a. Nucleoside reverse transcriptase inhibitors Abacavir, Didanosine, Lamivudine, Stavudine, Zalcitabine, Zidovudine b. Protease inhibitors Indinavir, Nelfinavir, Ritonavir, Saquinavir c. Non-nucleoside reverse transcriptase inhibitors Delavirdine, Efavirenz d. Other HIV medications Enfurvirtide e. Anti-CMV agents Cidofovir, Foscarnet, Ganciclovir f. Others Ribavirin 2. Antibacterials a. Quinolones Alatrofloxacin, Ciprofloxacin, Levofloxacin Norfloxacin, Trovafloxacin b. Tetracyclines Demeclocycline, Monocycline c. Macrolides Azithromycin, Clarithromycin d. Antituberculars Dapsone, Rifapentine e. Others Atovaquone, Ertapenem, Nitrofurantoin, Trimethoprim/Sulfamethoxazole, Quinpristin/Dalfopristin 3. Antifungal Voriconazole B. Cardiovascular agents 1. Antihypertensives a. ACE-I Benzapril, Captopril, Enalapril, Fosinopril, Lisinopril, Moexipril, Quinapril, Ramipril, Trandolapril d. Diuretics Thiazide diuretics Bendroflumethiazide, Cholorothiazide, Hydrochlorothiazide, Metolazone, Polythiazide Loop diuretics Ethacrynic acid#, Furosemide c. a2-Agonists Methyldopa, Prazosin d. Calcium channel blockers Amlodipine 2. Cholesterol lowering agents a. HMG-CoA reductase inhibitors Atorvastatin, Fluvastatin, Levastatin, Pravastatin Simvastatin b. Fibrates Gemfibrozil, Fenofibrate, 3. Anti-platelets/thrombolytics Aspirin, Alteplase, Anagrelide, Dipyridamole, Reteplase, Streptokinase 4. Anti-arrhythmics Amiodarone, Mexiletine TABLE 3. (continued) All Medications Implicated in Pancreatitis C. Neuropsychiatric agents 1. Anticonvulsants Carbamazepine, Divalproex sodium, Felbamate, Gabapentin, Lamotrigine, Topiramate, Valproic acid 2. Anticholinesterase Tacrine, Rivastigmine 3. Selective serotonin agonists Sumatriptan, Zolmitriptan 4. Atypical antipsychotics Aripiprazole, Clozapine, Olanzapine, Quetiapine, Risperidone 5. Antidepressants a. SSRIs Citalopram, Escitalopram, Fluoxetine, Paroxetine Sertraline b. Others Bupropione, Mertazapine, Venlaflaxine D. Antineoplastic agents 1. Breast cancer medications Alemtuzumab, Trastuzumab, Doxorubicin, Tamoxifen 2. Leukemia medications Asparaginase, Pegasparaginase 3. Lung cancer medications Gefitinib, Vinorelbine 4. Colon cancer medications Oxaliplatin, Levamisole 5. Others Methotrexate E. Anti-inflammatory agents 1. NSAIDs Diclofenac, Ibuprofen, Ketorolac, Meloxicam, Sulindac Mefenamic acid, Nabumetone, Naproxen, Piroxicam 2. COX-II inhibitors Celecoxib, Rofecoxib F. GI agents 1. PPIs Omeprazole, Pantoprazole, Rabeprazole 2. Antacids Cimetidine, Ranitidine 3. IBD medications a. Aminosalicylates Balsalazide, Mesalamine, Olsalazine, Sulfasalazine b. Others Azathioprine, Mercaptopurine G. Hormones 1. Steroids Cortisone, Dexamethasone, Fludrocortisone, Methylprednisolone, Prednisone 2. Estrogens Conjugated estrogens, Ethinyl estradiol, Estradiol 3. Others Somatropin, Octreotide H. Immunomodulators Cyclosporine, Glatiramer, Interferon b-1B, Interferon g-1B, Mycophenolate, Sirolimus, Tacrolimus, Thalidomide, Peginterferon a-2B I. Vitamins Acitretin, Calcitriol, Tretinoin Doxercalciferol, Isotretinoin J. Parasympathetic Agents Pilocarpine, Rivastigmine, Tacrine K. TNF-a Inhibitors Etanercept, Infliximab L. Others MMR vaccine live, Montelukast, Penicillamine, Pergolide, Propofol, Repaglinide, Riluzole, Ropirinole --->


 * diabetes-drugs-may-cause-damage-to-pancreas


 * Liraglutide (Victoza)-It has the potential for inhibiting apoptosis and stimulating regeneration of beta cells (seen in animal studies).
 * Exenatide (Byetta)


 * Albiglutide
 * Taspoglutide