User:Patelurology2/Medical Controversies, Conundra & Paradoxes

Medical Controversies, Conundra & Paradoxes  new article content ... ---Key words and titles are: Challenging Conventional Wisdom, Confusions, Complexities, Corollaries from Conventional Wisdom, Assocation Redux, Demythify, Paradoxical 'Contango' of Medical Progress-seemingly a Circumstantial Regression, Medical practices Reversal http://www.mayoclinicproceedings.org/article/S0025-6196(13)00405-9/fulltext See below this line in edit mode: work in progress regarding Vit E Se Fish oil... update coming soon written 10/15/13 <!--- Vit E: 4 tocoph ( weaker? than tocotrs ) + 4 tocotr -- alpha opposes ( bully ) gamma in some respect= gammas with anti nitration ( scavenges reactive nitrogen species- ? more important for neoplasia? ) get opposed or nulled or none available after high alpha tocoph ( that to synthetics variety- may not matter in this regard? except it was the active form and worked to detriment, somewhat ) prevails over the gamma--- molecule of tocoph to molecule of tocotr ( stronger but if molecules of tocoph added take the seat, no much room for strongers' effect relatively ) substitution takes anti-nitration ( ? more important than antioxidant effect of alpha-- gamma also has antiox effect ) to the dumps. Effect of synthetics vs naturals complicates further. Heated oils may have denatured vit E? Can denature vit e get in as far as to take a seat? i.e. occupy receptor? or modulate a process?
 * A concept worthy of discussion at the Village Pump-- i.e the tiltle of a page can be evolving till launch and possibly beyond- thus the page lable is to be considered a placeholder e.g in this case more being added to the tiltle:

http://lpi.oregonstate.edu/ss03/vitamine.html

http://www.lef.org/featured-articles/vitamin_e_01.htm

I believe Vit E ( what type and how much ) and Se ( what type and how much: Rutgers basic sci Piscataway has some work done a decade ago that relationship was noted to be bell shaped optimal at 200 microgm- again type and in whom to avoid ) both have roles and in whom they be avoided is the Q- genetic is one aspect, the other we need to define based on basic chem of the chemicals involved. Some chemicals/ bio-nutrients in which we have yet to define active ingredient may modulate genes; canonical processes are easy to understand and well established. As we progress every other sentence might come out as modulating this or the other gene....

Se - salt/ protein ?better. genetic differences in the person's biochem and that of the tissue e g prostate cell whether cancerous or benign has differing genetics- some types Se acts as anti-neoplastic and others the opposite e.g in Mn SOD complex: AA ( se cause antineopl effect ) AV VV ( proneopl )-- there are others like this

Now out of above study comes some data briefly shown in the summary below, but I have yet to read about the characteristics of those who got and who didn't get ca p in the analysis of fishy story (below )with respect to the vit e and or sel used. No one even opined as to why EPA DPA DHA are high in those ( though were only marginally so-- people who take those supplements have those levels much higher, as per my reading ) e.g. / D6d D5d modulation preferentially to omega 3 channel ? for whatever reason e.g had more/less selenium"s beneficial/adverse effect? that is e.g.

In one of the studies from Toronto - basic research where s phase decrease was noted a graph on vit e se both at 24 48 72 hrs - does point to se+e work beyond 72 with incr beneficial effect in PC-3 but se alone trails down at 48 hrs --- http://www.ncbi.nlm.nih.gov/pubmed/14745439

fish oil story http://cardiobrief.org/2013/07/11/link-to-prostate-cancer-brings-more-bad-news-for-fish-oil-story/

Ca P: Low grade under observation - can benefit from learned dietary modulation - above complex maze can be solved & tracked and likes of green tea, lycopene, vit d, soy etc etc can be incorporated as well. Exercise tames the neoplastic gene; sexercise may drain the pollutants. Prophylactic prostatectomy like mastectomy in BRCA complex not ready yet-- Ca p slow, all above can be incorporated and benefit expected but sorting the maze is imp. --->


 * An example of controvercy/conundrum/paradox: Vit D and Prostete cancer interaction
 * Journal of Clinical Laser Medicine & Surgery:Conundrums, Paradigms, and Paradoxes
 * Vitamin E may increase prostate Ca risk, analysis of SELECT data shows:Oct 20, 2011:Urology Times eNews
 * Linus Pauling Institute: Micronutrient Research for Optimum Health
 * Which Form of Vitamin E, Alpha- or Gamma-Tocopherol, is Better?:Maret G. Traber, Ph.D.:Professor of Nutrition:LPI Principal Investigator


 * An example of an otherwise approved therapy being revoked : Avastin

Vit E

 * On the problematic nature of vitamin E requirements: net vitamin E
 * Relationship between vitamin E requirement and polyunsaturated fatty acid intake in man: a review
 * Human requirement for N-3 polyunsaturated fatty acids
 * The tocopherol, tocotrienol, and vitamin E content of the average Finnish diet
 * Palm oil-derived natural vitamin E alpha-tocotrienol in brain health and disease
 * Tocotrienols: the emerging face of natural vitamin E
 * Tocotrienols in health and disease: the other half of the natural vitamin E family
 * An update on vitamin E, tocopherol and tocotrienol-perspectives.to prevent lipid oxidation, the plants mainly accumulate tocochromanols in oily seeds and fruits or in young tissues undergoing active cell divisions
 * Biosynthesis, regulation and functions of tocochromanols in plants
 * Functional diversity of tocochromanols in plants