User:Peter.C/Phys

Pathophysiology
After sustaining an traumatic injury various systemic and local effects occur to the body. The response to trauma is an attempt to ensure the protection of vital organs, such as the liver, allow for further cellular replication, and to heal the damage caused. Factors such as, sex, age, and severity of the injury will determine how long the process of recovery will take.

Inflammation is a common reaction to injury which is a defense mechanism to remove injurious stimuli and to initiate the healing process. If there is an overload of pro and anti-inflammatory mechanisms it can cause organ failure. The first metabolic change after injury is a catabolic state in which there is an increase in gluconeogenesis and lipolysis. This is followed by an anabolic state, all of the bodies energy stores, such as glucose and proteins. In this state the body will temporarily increase its maximum expenditure.