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While these treatments have been recommended, there is still a lack of research on the best and most efficacious treatments for complex PTSD. Psychological therapies such as cognitive behavioural therapy, eye movement desensitisation and reprocessing therapy are effective in treating CPTSD symptoms like PTSD, depression and anxiety. They are especially effective for complex trauma related to domestic violence and less effective when the condition is related to experiences of war or childhood sexual abuse. For CPTSD due to war or childhood sexual abuse mixing elements of different therapies seems to work better. Mindfulness and relaxation is effective for PTSD symptoms, emotion regulation and interpersonal problems for people whose complex trauma is related to sexual abuse.

Antipsychotic medicine can help reducing PTSD symptoms for veterans.

Many commonly used treatments are considered complementary or alternative since there still is a lack of research to classify these approaches as evidence based.