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Medical Uses
Emtricitabine/rilpivirine/tenofovir is indicated for treatment of HIV-1 in adults naïve to HIV-1 medications (where the virus has not developed resistance to these anti-HIV medications) and who have no more than 100,000 copies per mL of HIV-1 RNA in their blood (“viral load”).

Dosage Forms
COMPLERA: Each tablet contains 200 mg emtricitabine, 25 mg rilpivirine, 300 mg tenofovir disoproxil fumarate

EVIPLERA: Each film-coated tablet contains 200 mg emtricitabine, 25 mg rilpivirine (as hydrochloride), 245 mg tenofovir disoproxil

Side Effects
Common Side Effects
 * Diarrhea
 * Nausea
 * Vomiting
 * Insomnia
 * Abnormal dreams
 * Dizziness
 * Headache
 * Rash
 * Weakness
 * Decreased appetite

Serious Side Effects


 * Lactic acidosis (excess lactic acid in blood) is a rare and potentially fatal side effect. It is characterized by the following symptoms: deep and rapid breathing, tiredness or weakness, nausea, vomiting, abnormal muscle pain, dizziness or drowsiness
 * Serious liver problems, such as hepatomegaly (enlarged liver) and steatosis (fatty liver). Presentation typically includes: skin or the white part of the eyes turning yellow (jaundice), dark “tea-colored” urine, light-colored bowel movements, loss of appetite, nausea, stomach pain
 * Worsening of hepatitis B (HBV) infection. Patients also diagnosed with HBV who stop taking Emtricitabine/rilpivirine/tenofovir may suddenly exacerbate their hepatitis.
 * New or worsening kidney problems, including kidney failure
 * Onset of depressive disorders or mood changes
 * Changes in bone such as osteonecrosis (breakdown and death of bone)
 * Increases or redistribution of body fat
 * Immune system changes (eg. Immune Reconstitution Syndrome)

Drug-Drug Interactions
Contraindications

Use of Emtricitabine/rilpivirine/tenofovir with the following medicines is contraindicated, as they lead to reduced blood levels of rilpivirine and in turn reduce the effectiveness of Emtricitabine/rilpivirine/tenofovir:
 * carbamazepine, oxcarbazepine, phenobarbital, phenytoin
 * rifampicin, rifapentine
 * omeprazole, esomeprazole, lansoprazole, pantoprazole, rabeprazole
 * systemic dexamethasone (more than a single dose)
 * St John’s wort

Precautions

Emtricitabine/rilpivirine/tenofovir must be appropriately spaced with the following medications:
 * Antacid medications containing aluminum, magnesium hydroxide, or calcium carbonate. Take at least 2 hours before or at least 4 hours after taking Emtricitabine/rilpivirine/tenofovir.
 * Other medications inhibiting stomach acid release, including cimetidine, famotidine, or ranitidine. Take at least 12 hours before or at least 4 hours after taking Emtricitabine/rilpivirine/tenofovir.