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Eric Wickstrom

Eric Wickstrom, Ph.D. (December 21, 1946) is a Professor of Biochemistry and Molecular Biology in the Sidney Kimmel Medical College at Thomas Jefferson University in Philadelphia.

Prof. Wickstrom and his coworkers design genetic therapy agents to block cancer gene activity and restore immune cell attacks on cancer cells. Prof. Wickstrom and his coworkers also design nuclear medicine genetic probes to visualize the activity of cancer genes. The nuclear medicine genetic probes also serve as companion diagnostics to reveal tumor accumulation and therapeutic efficacy of genetic therapy agents.

Education

•	1964-1968: Bachelor of Sciences with Honor, Biology, California Institute of Technology, Pasadena, California, mentored by Prof. Jerome Vinograd

•	1968-1972: Doctor of Philosophy, Chemistry, University of California, Berkeley, California, mentored by Prof. Ignacio Tinoco •	1973-1974: Research Associate, Chemistry, and Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, mentored by Prof. Michael Yarus

Books

•	Wickstrom, E., ed. (1998) Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors, Marcel Dekker, New York, ISBN 0-8247-0085-6

•	Wickstrom, E., ed. (1991) Prospects for Antisense Nucleic Acid Therapy of Cancer and AIDS, Wiley-Liss, New York, ISBN 0-471-56880-5

Selected Chapters and Reviews

•	Wickstrom, E. (2015) DNA and RNA derivatives to optimize distribution and delivery. Advanced Drug Delivery Reviews 87:25–34

•	Sethi, D., Thakur, M. L., and Wickstrom, E. (2012) Receptor-specific peptides for targeting of liposomal, polymeric, and dendrimeric nanoparticles in cancer diagnosis and therapy. Current Molecular Imaging 1(1):3-11

•	Wickstrom, E., and Thakur, M. L. (2010) Genetic and molecular approaches to imaging breast cancer. In: Sauter, E. R., and Daly, M. B., eds., Breast Cancer Risk Reduction and Early Detection, Springer, Boston, Chap. 9, 163-182

•	Wickstrom, E., and Thakur, M. L. (2006) Imaging cancer gene activity in patients from outside the body. Biotechnology Healthcare 2(2):45-48

•	Tian, X., Chakrabarti, A., Amirkhanov, N., Aruva, M., Zhang, K., Mathew, B., Cardi, C., Qin, W., Sauter, E. R., Thakur, M. L., and Wickstrom, E. (2005) External imaging of CCND1, MYC and KRAS oncogene mRNAs with tumor-targeted radionuclide-PNA-peptide chimeras. In El-Deiry, W., ed., Tumor Progression and Therapeutic Resistance, Annals of the New York Academy of Sciences, 1059:106-144

•	Smith, J. B., and Wickstrom, E. (2000) Preclinical antisense DNA therapy of cancer in mice. In Phillips, M. I., ed., Methods in Enzymology 314, Antisense Technology, Part B, Academic Press, Orlando FL, 537-580

Selected Scientific Papers

•	Oh, E., Liu, Y., Sonar, M.V., Merry, D.E., and Wickstrom, E. (2018) Fluorescence imaging of huntingtin mRNA knockdown. Bioconjugate Chemistry 29(4):1276-1282

•	Jin, Y.Y., Andrade, J., and Wickstrom, E. (2015) Non-specific blocking of miR-17-5p guide strand in triple negative breast cancer cells by amplifying passenger strand activity. PLoS One 10(12):e0142574

•	Sonar, M.V., Wampole, M.E., Jin, Y.Y., Chen, C.P., Thakur, M.L., and Wickstrom, E. (2014) Fluorescence detection of KRAS2 mRNA hybridization in lung cancer cells with PNA-peptides containing an internal thiazole orange. Bioconjugate Chemistry 25(9):1697-1708

•	Paudyal, B., Zhang, K., Chen, C.P., Wampole, M.E., Mehta, N., Mitchell, E.P., Gray, B.D., Mattis, J.A., Pak, K.Y., Thakur, M.L., and Wickstrom, E. (2013) Determining efficacy of breast cancer therapy by PET imaging of HER2 mRNA. Nucl Med Biol 40(8):994-999 •	Sanders, J.M., Wampole, M.E., Chen, C.P., Sethi, D., Singh, A., Dupradeau, F.Y., Wang, F., Gray, B.D., Thakur, M.L., and Wickstrom, E. (2013) Effects of hypoxanthine substitution in peptide nucleic acids targeting KRAS2 oncogenic mRNA molecules: theory and experiment. J Phys Chem B 117(39):11584-11595

•	Sethi, D., Chen, C.P., Jing, R.Y., Thakur, M.L., and Wickstrom, E. (2012) Fluorescent peptide-PNA chimeras for imaging monoamine oxidase A mRNA in neuronal cells. Bioconjugate Chemistry 23(2):158-163

•	Amirkhanov, N.V., Zhang, K., Aruva, M.R., Thakur, M.L., and Wickstrom, E. (2010) Imaging human pancreatic cancer xenografts by targeting mutant KRAS2 mRNA with [(111)In]DOTA(n)-poly(diamidopropanoyl)(m)-KRAS2 PNA-D(Cys-Ser-Lys-Cys) nanoparticles. Bioconjugate Chemistry 21(4):731-740

•	Amirkhanov, N.V., Dimitrov, I., Opitz, A.W., Zhang, K., Lackey, J.P., Cardi, C.A., Lai, S., Wagner, N.J., Thakur, M.L., and Wickstrom, E. (2008) Design of (Gd-DO3A)n-polydiamidopropanoate-peptide nucleic acid-D(Cys-Ser-Lys-Cys) magnetic resonance contrast agents. Biopolymers 89(12):1061-1076

•	Cesarone, G., Edugupanti, O.P., Chen, C.-P., and Wickstrom, E. (2007) Insulin receptor substrate 1 knockdown in human MCF7 estrogen receptor-positive breast cancer cells by nuclease-resistant IRS1 siRNA conjugated to a disulfide-bridged D-peptide analog of insulin-like growth factor 1. Bioconjugate Chemistry 18(6):1831-1840

•	Tian, X., Aruva, M.R., Zhang, K., Cardi, C.A., Thakur, M.L., and Wickstrom, E. (2007) PET imaging of CCND1 mRNA in human MCF7 estrogen receptor-positive breast cancer xenografts with an oncogene-specific [64Cu]DO3A-PNA-peptide radiohybridization probe. Journal of Nuclear Medicine 48(10):1699-1707

•	Vorobjev, P.E., Smith, J.B., Pyshnaya, I.A., Levina, A.S., Zarytova, V.F., and Wickstrom, E. (2003) Site-specific cleavage of RNA and DNA by complementary DNA-bleomycin A5 conjugates. Bioconjugate Chemistry 14(6):1307-1313

•	Smith, J.B. and Wickstrom, E. (1998) Antisense c-myc and immunostimulatory oligonucleotide inhibition of tumorigenesis in a murine B-cell lymphoma transplant model. Journal of the National Cancer Institute 90(15):1146-1154 •	Huang, Y., Snyder, R., Kligshteyn, M., and Wickstrom, E. (1995) Prevention of tumor formation in a mouse model of Burkitt's lymphoma by 6 weeks of treatment with anti-c-myc DNA phosphorothioate. Molecular Medicine 1(6):647-658 •	Wickstrom, E., Bacon, T.A., and Wickstrom, E.L. (1992) Down-regulation of c-Myc antigen expression in lymphocytes of Eµ-c-myc transgenic mice treated with anti-c-myc DNA methylphosphonates. Cancer Research 52(24):6741-6745 •	Wickstrom, E.L., Bacon, T.A., Gonzalez, A., Freeman, D.L., Lyman, G.H., and Wickstrom, E. (1988) Human promyelocytic leukemia HL-60 cell proliferation and c-Myc protein expression are inhibited by an antisense pentadecadeoxynucleotide targeted against c-MYC mRNA. Proceedings of the National Academy of Sciences USA 85(4):1028-1032