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Juncosamine is a conformationally constrained analogue of the N-benzylphenethylamine 25B-NBOMe and was discovered in 2011 by Jose Juncosa in the group of David E. Nichols at Purdue University. The (S,S) isomer of Juncosamine is the most selective agonist ligand for the 5-HT2A receptor yet discovered, with a Ki of 2.5 nM at the human 5-HT2A receptor and with 124-fold selectivity for 5-HT2A over the structurally homologous 5-HT2C-receptor. Together with 25CN-NBOH, Juncosamine is the only 5-HT2A agonist to exhibit this level of selectivity.