User:Poprocks1/Fight-or-flight response

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The fight-or-flight or the fight-flight-or-freeze (also called hyperarousal or the acute stress response) is a physiological reaction that occurs in response to a perceived harmful event, attack, or threat to survival. It was first described by Walter Bradford Cannon. His theory states that animals react to threats with a general discharge of the sympathetic nervous system, preparing the animal for fighting or fleeing. More specifically, the adrenal medulla produces a hormonal cascade that results in the secretion of catecholamines, especially norepinephrine and epinephrine. The hormones estrogen, testosterone, and cortisol, as well as the neurotransmitters dopamine and serotonin, also affect how organisms react to stress. The hormone osteocalcin might also play a part.

This response is recognized as the first stage of the general adaptation syndrome that regulates stress responses among vertebrates and other organisms.

Autonomic nervous system
The autonomic nervous system is a control system that acts largely unconsciously and regulates heart rate, digestion, respiratory rate, pupillary response, urination, and sexual arousal. This system is the primary mechanism in control of the fight-or-flight response and its role is mediated by two different components: the sympathetic nervous system and the parasympathetic nervous system.

Sympathetic nervous system
The sympathetic nervous system originates in the spinal cord and its main function is to activate the arousal responses that occur during the fight-or-flight response. The sympathetic nervous system transfers signals from the dorsal hypothalamus, which activates the heart, increases vascular resistance, and increases blood flow, especially to the muscle, heart, and brain tissues. It activates the adrenal medulla, releasing catecholamines that amplify the sympathetic response. Additionally, this component of the autonomic nervous system utilizes and activates the release of norepinephrine by the adrenal glands in the reaction.

Parasympathetic nervous system
The parasympathetic nervous system originates in the sacral spinal cord and medulla, physically surrounding the sympathetic origin, and works in concert with the sympathetic nervous system. It is known as the calming portion of the autonomic nervous system. While the sympathetic nervous system is activated, the parasympathetic nervous system decreases its response. Efferent vagal fibers originating from the nucleus ambiguous fire in parallel to the respiratory system, decreasing the vagal cardiac parasympathetic tone. After the fight or flight response, the parasympathetic system's main function is to activate the "rest and digest" response and return the body to homeostasis. This system utilizes and activates the release of the neurotransmitter acetylcholine.

Reaction
The reaction begins in the amygdala, which triggers a neural response in the hypothalamus. The initial reaction is followed by activation of the pituitary gland and secretion of the hormone ACTH. The adrenal gland is activated almost simultaneously, via the sympathetic nervous system, and releases the hormone epinephrine. The release of chemical messengers results in the production of the hormone cortisol, which increases blood pressure, blood sugar, and suppresses the immune system.

The initial response and subsequent reactions are triggered in an effort to create a boost of energy. This boost of energy is activated by epinephrine binding to liver cells and the subsequent production of glucose. Additionally, the circulation of cortisol functions to turn fatty acids into available energy, which prepares muscles throughout the body for response.

Catecholamine hormones, such as adrenaline (epinephrine) or noradrenaline (norepinephrine), facilitate immediate physical reactions associated with a preparation for violent muscular action and:

Function of physiological changes
The physiological changes that occur during the fight or flight response are activated in order to give the body increased strength and speed in anticipation of fighting or running. Some of the specific physiological changes and their functions include:


 * Increased blood flow to the muscles activated by diverting blood flow from other parts of the body to make taking quick action easier.
 * Increased blood pressure and heart rate enhance cardiac output in order to supply the body with more energy.
 * Increased blood sugar (glucose) and fats secreted by the liver to provide the body with extra fuel.
 * Increased respiration to supply the oxygen necessary to help burn the extra glucose.
 * The blood clotting function of the body speeds up in order to prevent excessive blood loss in the event of an injury sustained during the response.
 * Increased muscle tension in order to provide the body with extra speed and strength, which can result in trembling or shaking until the tension is released.
 * The pupils dilate to let in more light, allowing for better vision of the body's surroundings.

Evolutionary perspective[edit]
An evolutionary psychology explanation is that early animals had to react to threatening stimuli quickly and did not have time to psychologically and physically prepare themselves. The fight or flight response provided them with the mechanisms to rapidly respond to threats against survival.

Examples[edit]
A typical example of the stress response is a grazing zebra. If the zebra sees a lion closing in for the kill, the stress response is activated as a means to escape its predator. The escape requires intense muscular effort, supported by all of the body's systems. The sympathetic nervous system's activation provides for these needs. A similar example involving fight is of a cat about to be attacked by a dog. The cat shows accelerated heartbeat, piloerection (hair standing on end), and pupil dilation, all signs of sympathetic arousal. Note that the zebra and cat still maintain homeostasis in all states.

In July 1992, Behavioral Ecology published experimental research conducted by biologist Lee A. Dugatkin where guppies were sorted into "bold", "ordinary", and "timid" groups based upon their reactions when confronted by a smallmouth bass (i.e. inspecting the predator, hiding, or swimming away) after which the guppies were left in a tank with the bass. After 60 hours, 40 percent of the timid guppies and 15 percent of the ordinary guppies survived while none of the bold guppies did.