User:Ppenzes

Peter Penzes

Peter Penzes (born May 11, 1968) is an American neuroscientist of Romanian and Hungarian origin. Penzes is a Ruth and Evelyn Dunbar Professor in the Departments of Physiology, Psychiatry and Behavioral Sciences, and Pharmacology at the Northwestern University Feinberg School of Medicine, and director of the Northwestern University Center for Autism and Neurodevelopment.

Biography

Penzes was born in Sighet, Romania. In his youth, Penzes studied art under Dudas Gyula and Iuliu Dragos at the Colegiul de Arte in Baia Mare, and later with Csaba Andras and Uto Erzsebet. He graduated with a bachelor’s degree in biochemistry from the University of Bucharest and received his Ph.D. in biochemistry form the State University of New York at Buffalo under the guidance of Joseph L. Napoli. He conducted postdoctoral studies at the Johns Hopkins University School of Medicine in the Department of Neuroscience under Betty Eipper, Richard Mains, and then Richard Huganir.

In 2003, Penzes joined the faculty at Northwestern University Feinberg School of Medicine in Chicago, where he is currently a professor. He is the founding director of the Northwestern Center for Autism and Neurodevelopment

Research

Penzes’ research has focused on the biology and pathology of synapse s, the connections between brain cells. He has made seminal contributions to several research areas in neuroscience. He discovered several molecules that govern synaptic structural plasticity and the remodeling of dendritic spines, which are important in brain development and for learning and memory. Penzes’ laboratory has also shown that many genetic risk factors for psychiatric disorders and neurological disorders control the structure and function of synapses, and their malfunction underlies such diseases. Such disease risk molecules studied in Penzes’ laboratory include: kalirin (KALRN), CNTNAP2  , SHANK3, ankyrin-G (ANK3)  , USP9X , AMPA and NMDA receptors , BIN1 , ephrins and Eph receptors, and synaptic adhesion molecules. Penzes has made important contributions to the understanding of the biological bases of autism  , intellectual disability, epilepsy, schizophrenia , bipolar disorder  , and Alzheimer’s disease.

Select publications

Penzes has published over 100 articles in peer-reviewed journals.

Yoon S, Piguel NH, Khalatyan N, Dionisio LE, Savas JN, Penzes P. Homer1 promotes dendritic spine growth through ankyrin-G and its loss reshapes the synaptic proteome. Mol Psychiatry. 2021 Jan 4:10.1038/s41380-020-00991-1. doi: 10.1038/s41380-020-00991-1. Epub ahead of print. PMID: 33398084; PMCID: PMC8254828.

Zaccard CR, Shapiro L, Martin-de-Saavedra MD, Pratt C, Myczek K, Song A, Forrest MP, Penzes P. Rapid 3D Enhanced Resolution Microscopy Reveals Diversity in Dendritic Spinule Dynamics, Regulation, and Function. Neuron. 2020 Aug 5;107(3):522-537.e6. doi: 10.1016/j.neuron.2020.04.025. Epub 2020 May 27. PMID: 32464088; PMCID: PMC7879711.

Yoon S, Parnell E, Kasherman M, Forrest MP, Myczek K, Premarathne S, Sanchez Vega MC, Piper M, Burne THJ, Jolly LA, Wood SA, Penzes P. Usp9X Controls Ankyrin-Repeat Domain Protein Homeostasis during Dendritic Spine Development. Neuron. 2020 Feb 5;105(3):506-521.e7. doi: 10.1016/j.neuron.2019.11.003. Epub 2019 Dec 5. PMID: 31813652; PMCID: PMC7007386.

Schürmann B, Bermingham DP, Kopeikina KJ, Myczek K, Yoon S, Horan KE, Kelly CJ, Martin-de-Saavedra MD, Forrest MP, Fawcett-Patel JM, Smith KR, Gao R, Bach A, Burette AC, Rappoport JZ, Weinberg RJ, Martina M, Penzes P. A novel role for the late-onset Alzheimer's disease (LOAD)-associated protein Bin1 in regulating postsynaptic trafficking and glutamatergic signaling. Mol Psychiatry. 2020 Sep;25(9):2000-2016. doi: 10.1038/s41380-019-0407-3. Epub 2019 Apr 9. PMID: 30967682; PMCID: PMC6785379.

Gao R, Piguel NH, Melendez-Zaidi AE, Martin-de-Saavedra MD, Yoon S, Forrest MP, Myczek K, Zhang G, Russell TA, Csernansky JG, Surmeier DJ, Penzes P. CNTNAP2 stabilizes interneuron dendritic arbors through CASK. Mol Psychiatry. 2018 Sep;23(9):1832-1850. doi: 10.1038/s41380-018-0027-3. Epub 2018 Apr 9. PMID: 29610457; PMCID: PMC6168441.

Forrest MP, Parnell E, Penzes P. Dendritic structural plasticity and neuropsychiatric disease. Nat Rev Neurosci. 2018 Mar 16;19(4):215-234. doi: 10.1038/nrn.2018.16. PMID: 29545546; PMCID: PMC6442683.

Russell TA, Grubisha MJ, Remmers CL, Kang SK, Forrest MP, Smith KR, Kopeikina KJ, Gao R, Sweet RA, Penzes P. A Schizophrenia-Linked KALRN Coding Variant Alters Neuron Morphology, Protein Function, and Transcript Stability. Biol Psychiatry. 2018 Mar 15;83(6):499-508. doi: 10.1016/j.biopsych.2017.10.024. Epub 2017 Nov 7. PMID: 29241584; PMCID: PMC5809265.

Blizinsky KD, Diaz-Castro B, Forrest MP, Schürmann B, Bach AP, Martin-de-Saavedra MD, Wang L, Csernansky JG, Duan J, Penzes P. Reversal of dendritic phenotypes in 16p11.2 microduplication mouse model neurons by pharmacological targeting of a network hub. Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):8520-5. doi: 10.1073/pnas.1607014113. Epub 2016 Jul 11. PMID: 27402753; PMCID: PMC4968749.

Varea O, Martin-de-Saavedra MD, Kopeikina KJ, Schürmann B, Fleming HJ, Fawcett-Patel JM, Bach A, Jang S, Peles E, Kim E, Penzes P. Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2/Caspr2 knockout neurons. Proc Natl Acad Sci U S A. 2015 May 12;112(19):6176-81. doi: 10.1073/pnas.1423205112. Epub 2015 Apr 27. PMID: 25918374; PMCID: PMC4434727.

Smith KR, Kopeikina KJ, Fawcett-Patel JM, Leaderbrand K, Gao R, Schürmann B, Myczek K, Radulovic J, Swanson GT, Penzes P. Psychiatric risk factor ANK3/ankyrin-G nanodomains regulate the structure and function of glutamatergic synapses. Neuron. 2014 Oct 22;84(2):399-415. doi: 10.1016/j.neuron.2014.10.010. Epub 2014 Oct 22. PMID: 25374361; PMCID: PMC4223651.

Penzes P, Cahill ME, Jones KA, VanLeeuwen JE, Woolfrey KM. Dendritic spine pathology in neuropsychiatric disorders. Nat Neurosci. 2011 Mar;14(3):285-93. doi: 10.1038/nn.2741. PMID: 21346746; PMCID: PMC3530413.

Jones KA, Srivastava DP, Allen JA, Strachan RT, Roth BL, Penzes P. Rapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19575-80. doi: 10.1073/pnas.0905884106. Epub 2009 Nov 4. PMID: 19889983; PMCID: PMC2780750.

Xie Z, Srivastava DP, Photowala H, Kai L, Cahill ME, Woolfrey KM, Shum CY, Surmeier DJ, Penzes P. Kalirin-7 controls activity-dependent structural and functional plasticity of dendritic spines. Neuron. 2007 Nov 21;56(4):640-56. doi: 10.1016/j.neuron.2007.10.005. PMID: 18031682; PMCID: PMC2118058.

External links

https://sites.northwestern.edu/penzeslab/

http://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=16355

http://www.feinberg.northwestern.edu/sites/autism-neurodevelopment/

REFERENCES