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Polyhydroamine is an antimicrobial solution used in treating nail fungus infections or onychomycosis and sold under the trade name Toemate. The mixture includes bis (hydrogenated alkyl methyl amines) hydrochloride, hydrogen peroxide, isopropyl alcohol and water that are FDA and or EPA approved with no side effects at concentrations under 0.05%. Infected nails are soaked in warm1 polyhydroamine for 10 minutes once daily for one to three months depending on the severity of the infection.

Results improve standard topical treatments2 with ingredients dissolved in water3 and complimentary modes of action4 that soak nails in a warm polyhydroamine solution5 (nails absorb warm water and become soft). The average treatment cost is less than $10 per nail.

1. Gupchup-Malhotra G, Zatz J. Characterization of the physical factors affecting nail permeation using water as a probe. Journal of Cosmetic Science 2000 51, pp. 367-377.

2. Favre B. et al 2003 Comparison of In Vitro Activities of 17 Antifungal Drugs against a Panel of 20 Dermatophytes byProduct Information Using a Microdilution Assay Journal Of Clinical Microbiology Vol. 41 No. 10 p. 4817–4819

3. Kobayashi, Y.,  Komatsu, T.,  Sumi,  M., Numajiri,  S.,  Miyamoto, M.,  Kobayashi,  D., et al. In vitro permeation of several drugs through the human nail plate: relationship between physicochemical properties and nail permeability of drugs. European Journal of Pharmaceutical Sciences. 2004 21:4 pp. 471-477.

4. Baran R, Kaoukhov, A. Topical antifungal drugs for the treatment of nail fungus: an overview of current strategies for monotherapy and combination therapy. Journal of the European Academy of Dermatology and Venereology. 2005 Volume 19, Issue 1, pages 21–29

5. Kobayashi, Y., Miyamoto,  M.,  Sugibayashi,  K., Morimoto, Y. Drug Permeation through the Three Layers of the Human Nail Plate. Journal of Pharmacy and Pharmacology, 1999 51, pp. 271-278.