User:Prashanthrajasekar/sandbox

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Chronic Lymphocytic Leukemia

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Practice Editing Here (Nov 15th in-class Wiki session work)

 * This is a place to practice clicking the "edit" button and practice adding references (via the citation button).

Task:


 * 1) Find a peer-reviewed journal article on PubMed. Practice inserting your citation in the above space using the "cite" tool
 * 2) Choose one "B-level" medical article on Wikipedia from the following list: https://wp1.openzim.org/#/project/Medicine/articles?quality=B-Class&importance=High-Class
 * 3) Practice editing live on Wikipedia by finding a typo in the text or improving the clarity/readability of a sentence by adjusting a few words in a sentence.

Assignment # 3- please post an anonymous copy here!
Proposed Changes

1.     The sentence that I wish to change is currently published as “In CLL, the lymphocytes are genetically clonal, of the B cell lineage (expressing marker molecules clusters of differentiation 19 and 20), and characteristically express the marker molecules CD5 and CD23.”

I would like to expand on the term “genetically clonal” since a layperson may not understand this. I would also like to expand on what differentiation 19 and 20 are.

“In CLL, the lymphocytes are all genetically identical since they are derived from the same B cell lineage (and therefore express the same detectable patterns of surface markers, specifically, clusters of differentiation 19 and 20), containing the surface marker molecules CD5 and CD23.”

Rationale for Proposed Changes

2.     The reason for the proposed change is to clarify terms that may not be clear to laypersons but have fairly simple definitions. Genetically clonal for example, simply means, the cells are identical and come from the same cell line. Similarly, clusters of differentiation simply mean that they have the same patterns of surface antigens. These are simple concepts with intimidating vocabulary and therefore, simple expansions can make this sentence more easily understood by the general audience. The definitions and clarifications were derived from the following resource:

Strati, P., Jain, N., & O'Brien, S. (2018). Chronic Lymphocytic Leukemia: Diagnosis and Treatment. Mayo Clinic proceedings, 93(5), 651–664. https://doi.org/10.1016/j.mayocp.2018.03.002

3.     This change may be controversial because it is avoiding the use of common medical vocabulary, which allows for a short and precise sentence. Though this may be preferable for a scientifically literate audience, the proposed change makes this information more accessible for

Critique of Sources

4.     The source that I found didn’t seem to have any noticeable bias and was rather focused on presented detailed biochemical information on Chronic Lymphocytic Leukemia. The article provides enough depth and detail that concepts are easy to understand in detail and medical jargon is expanded on. I used this to ensure that I understood what was being explained and rewrote the sentence with more layperson friendly language to reflect this understanding to a general audience.

What to post on the Wikipedia article talk page (part of assignment 3)

 * This will also be covered on Nov 15th in class. Your group should use the below template to share an outline of your proposed improvements (including your new wording and citations). Article talk pages are not places to share your assignment answers. The Wikipedia community will be more interested in viewing your exact article improvement suggestions including where you plan to improve the article (which section), what wording you suggest, and the exact citation (Note: all citations must meet WP:MEDRS)
 * You will not be able to paste citations directly from your sandbox to talk pages (unless you are interested in editing/learning Wiki-code in the "source editing" mode). We suggest re-adding your citations on the talk page manually (using the cite button and populating the citation by pasting in the DOI, website, or PMID). You will have to repeat this process yet again when you edit the actual article live.
 * Talk Page Template: CARL Medical Editing Initiative/Fall 2021/Talk Page Template