User:Prikale/Choose an Article

Article Selection
Please list articles that you're considering for your Wikipedia assignment below. Begin to critique these articles and find relevant sources.

Option 1

 * Article title: X-inactivation
 * Article Evaluation: While this article does specify the details of skewed X-inactivation, it does fully describe the consequences or effects of such an "imbalanced" distribution among the female population. Specifically, the article, authored by Veyver, attached explains how one extreme consequential reaction is the development or increased expression of phenotypically, recessive, X-linked diseases. I think it may be important to explain the epigenetic details behind how this disease may be triggered, possibly by environment or behavior, and explain the mechanism behind its development. The talk page describes this issue and for it has written another page specifically for skewed distribution where phenotypically recessive diseases are detailed. However, both this added page and the original article fail to detail the manners of activation and what changes in surrounding or behavior can either stimulate or silence transcription of otherwise silenced or up-regulated genes, respectively. The Balaton article details the mechanisms that I believe are important to understanding how the recessive genes can be suppressed or silenced and lead to development of diseases, such as breast cancer. In relation to environmental triggers, it is something that has not reached definitive results but is a detail I am curious about and unsure whether it is important to include or not.
 * Sources
 * Van den Veyver, I B. “Skewed X inactivation in X-linked disorders.” Seminars in reproductive medicine vol. 19,2 (2001): 183-91. doi:10.1055/s-2001-15398
 * Balaton, Bradley P, and Carolyn J Brown. “Contribution of genetic and epigenetic changes to escape from X-chromosome inactivation.” Epigenetics & chromatin vol. 14,1 30. 29 Jun. 2021, doi:10.1186/s13072-021-00404-9
 * Van den Veyver, I B. “Skewed X inactivation in X-linked disorders.” Seminars in reproductive medicine vol. 19,2 (2001): 183-91. doi:10.1055/s-2001-15398
 * Balaton, Bradley P, and Carolyn J Brown. “Contribution of genetic and epigenetic changes to escape from X-chromosome inactivation.” Epigenetics & chromatin vol. 14,1 30. 29 Jun. 2021, doi:10.1186/s13072-021-00404-9

Option 2

 * Article title: Skewed X-inactivation
 * Article Evaluation: Continuing my interest in X-inactivation in female chromatin and its relation to development of recessive X-linked diseases, I am also interested in editing this article. The talk page for the original "X-inactivation" Wikipedia page describes their issue with the lack of information regarding skewed X-inactivation and its consequences. To solve this, they had written another page specifically for skewed distribution. It seems since they created this page, more information regarding skewed distribution has been added to both the original Wikipedia page and this new article, leading to excessively redundant information for readers. I think this information can also be added onto either page but the information should be well organized and referenced. This article has detailed many Regardless of placement, I believe it to be important that the mechanisms of DNA methylation be detailed in relation to skewed X-inactivation, in relation to which genes can be silenced or have transcription levels reduced. I believe updating the articles referenced with more relevant data can also be important to ensuring the validity or scope of this article.
 * Sources
 * Chaligné, Ronan et al. “The inactive X chromosome is epigenetically unstable and transcriptionally labile in breast cancer.” Genome research vol. 25,4 (2015): 488-503. doi:10.1101/gr.185926.114
 * Sources
 * Chaligné, Ronan et al. “The inactive X chromosome is epigenetically unstable and transcriptionally labile in breast cancer.” Genome research vol. 25,4 (2015): 488-503. doi:10.1101/gr.185926.114

Option 3

 * Article title: Barr Body
 * Article Evaluation: This article is mainly redundant in that it can easily be merged with X-inactivation. With the amount of information on the article, it does not warrant a new page -- this critical evaluation is something also noted by editors on the Talk page for this article. I believe that this article can either be merged with X-inactivation or expanded. For one, the structure of Barr Bodies is not covered nor is its replication/mitiotic process. The second critique is noted in the Talk page. The page has few references that can surely be expanded, but they are well chosen. The structure and maintenance of Barr Body is not detailed but the mechanism of its creation is well explained. I am also interested in how the expression of Barr bodies can change with diseases, triggers, or aging. None of these changes are detailed in the article.
 * Sources
 * Giorgetti, L., Lajoie, B., Carter, A. et al. Structural organization of the inactive X chromosome in the mouse. Nature 535, 575–579 (2016). https://doi.org/10.1038/nature18589
 * Chadwick, Brian P, and Huntington F Willard. “Chromatin of the Barr body: histone and non-histone proteins associated with or excluded from the inactive X chromosome.” Human molecular genetics vol. 12,17 (2003): 2167-78. doi:10.1093/hmg/ddg229
 * Giorgetti, L., Lajoie, B., Carter, A. et al. Structural organization of the inactive X chromosome in the mouse. Nature 535, 575–579 (2016). https://doi.org/10.1038/nature18589
 * Chadwick, Brian P, and Huntington F Willard. “Chromatin of the Barr body: histone and non-histone proteins associated with or excluded from the inactive X chromosome.” Human molecular genetics vol. 12,17 (2003): 2167-78. doi:10.1093/hmg/ddg229

Option 4

 * Article title: Histone Octamer
 * Article Evaluation: This article details the composition of the histone and its interaction with DNA with well cited articles and recently published sources. However, I believe this article does not detail any of the epigenetic mechanisms, specifically as we have learned in this class. Understanding that changes in transcription levels can occur in response to changes in histone octamer structure is an important feature of epigenetics and the concepts of histones or nucleosomes. The article, along with those we have learned in class, details the effects of histone modifications on transcription levels and changes in recessive disorders.
 * Sources
 * Henikoff, Steven, and M Mitchell Smith. “Histone variants and epigenetics.” Cold Spring Harbor perspectives in biology vol. 7,1 a019364. 5 Jan. 2015, doi:10.1101/cshperspect.a019364
 * Sources
 * Henikoff, Steven, and M Mitchell Smith. “Histone variants and epigenetics.” Cold Spring Harbor perspectives in biology vol. 7,1 a019364. 5 Jan. 2015, doi:10.1101/cshperspect.a019364

Option 5

 * Article title: Epigenetics in learning and memory
 * Article Evaluation: I believe this article details the study of epigenetics in relation to the formation and maintenance of long term memory. Specifically, the area I think that can be improved is the sub topic of "Acetlylation as a mechanism for learning and memory." For this, I believe it is important to include the clinical advantages of epigenetic intervention as indicated in the article. This article notes that increasing histone acetylation is correlated with memory amelioration. I think updating this page with recently published articles and medical or clinical developments regarding histone acetylation are important. Additionally, noting the structure of histone acetylation and how the octamer changes. Most significantly, epigenetic changes and their effects on memory formation are not noted in the article and in recent years, have published many findings as found in the article below. The article notes the changes in neural differentiation as a person ages and details how therapeutic changes will "ameliorate neural decline during normal ageing."
 * Sources
 * Allison M Burns, Johannes Gräff, Cognitive epigenetic priming: leveraging histone acetylation for memory amelioration, Current Opinion in Neurobiology, Volume 67, 2021, Pages 75-84, ISSN 0959-4388, https://doi.org/10.1016/j.conb.2020.08.011.
 * Delgado-Morales, Raúl et al. “Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders.” Clinical epigenetics vol. 9 67. 29 Jun. 2017, doi:10.1186/s13148-017-0365-z
 * Allison M Burns, Johannes Gräff, Cognitive epigenetic priming: leveraging histone acetylation for memory amelioration, Current Opinion in Neurobiology, Volume 67, 2021, Pages 75-84, ISSN 0959-4388, https://doi.org/10.1016/j.conb.2020.08.011.
 * Delgado-Morales, Raúl et al. “Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders.” Clinical epigenetics vol. 9 67. 29 Jun. 2017, doi:10.1186/s13148-017-0365-z