User:Princessslayerr/Henipavirus

Article Draft
-copied from journal article

"During genome replication, the polymerase complex enters the 3′ genomic promoter in a similar manner as during transcription, but ignores the mRNA transcriptional signals at gene junctions, causing the polymerase to transcribe a full-length positive-sense antigenome. A promoter in the 3′ non-coding region of the antigenome serves as the location where synthesis of new, negative-sense genomic RNA begins. Newly made genomes can in turn, serve as templates for transcription (Lamb and Parks 2007) .To assemble virus particles, the genome replication process must be terminated, newly made genomes must be properly encapsidated, and regions of the cell membrane need to be prepared to accept budding nucleocapsids(Lamb and Parks 2007) . Polymerase complexes associated with packaged nucleocapsids are responsible for the next round of infection. The viral glycoproteins are typically synthesized in the endoplasmic reticulum (ER) and mature through the Golgi network to the cell membrane. The henipavirus F glycoproteins are a unique exception to the rule, as F protein processing and maturation occurs in the endosome (Diederich et al. 2005)."

Replication Cycle

 * 1) viral protein G attach to cell receptor ephrin-B2 (on neurons, smooth muscle, and endothelial cells surrounding small arteries).
 * 2) Fusion protein F connects viral envelope and host cell membrane, viral genome is released into host cell.
 * 3) encapsidated genome serves as template for viral mRNA synthesis, this transcription is initiated by the polymerase complex.