User:Professor L123/KDM1A

KDM1A

KDM1A (also referred to as LSD1/AOF2/BHC110) can act on mono- and dimethylated H3K4 and H3K9. This enzyme can have roles critical in embryogenesis and tissue-specific differentiation, as well as oocyte growth. KDM1A was the first demethylase to be discovered and thus it has been studied most extensively.
 * Deletion of the gene for KDM1A can have effects on the growth and differentiation of embryonic stem cells and can lead to embryonic lethality in knockout mice, who do not produce the KDM1A gene product.  KDM1A is also thought to play a role in cancer, as poorer outcomes can be correlated with higher expression of this gene.    Therefore, the inhibition of KDM1A may be a possible treatment for cancer.    KDM1A has many different binding partners, which may be necessary for its demethylation activity.