User:Puffysphere/Entopy

Entopy is a new medical term for the condition of having an IgE-mediated  allergy in a specific  organ such as the nose, even though skin-prick and  blood tests for allergies are negative. In conventional allergy, IgE antibodies against specific allergens are generated in the  lymph nodes. The IgE antibodies leave the lymph nodes by lymph vessels which empty into the bloodstream, and these antibodies are detectable in  blood tests for allergy. The genetic predisposition to develop conventional allergies is called atopy.

In atopic individuals, IgE antibodies are produced locally, at the site where the allergen enters the body,    as well as in the lymph nodes.

However, in entopic individuals, the entire process of sensitization to allergens seems to occur locally, in the mucous membrane that is exposed to the allergen and the lymphoid tissue associated with the mucous membrane.

In the nose
A new type of rhinitis called local allergic rhinitis has been described in a continuing medical education course. Category:Inflammations Category:Medical terms Category:Immune system disorders Category:Allergology