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The use of antisense oligonucleotides to modulate splicing has shown great promise as a therapeutic strategy for a variety of genetic diseases caused by splicing defects.

Recent studies have shown that RNA splicing can be regulated by a variety of epigenetic modifications, including DNA methylation and histone modifications.

Singh NN, Singh RN. Alternative splicing in spinal muscular atrophy underscores the pathogenic role of survival motor neuron protein. Essays Biochem. 2018 Oct 31;62(4):489-499. doi: 10.1042/EBC20180033. PMID: 30381419.

Fu XD, Ares M Jr (October 2014). "Context-dependent control of alternative splicing by RNA-binding proteins". Nature Reviews. Genetics. 15 (10): 689–701. doi:10.1038/nrg3778. PMID 25182195.