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AlloDx (Shanghai) Biotech Co, Ltd.
Allograft Diagnostics (AlloDx) Biotech Co.Ltd is a leading research and development company in the field of molecular diagnostics and clinical translation in organ transplantation. Based in Caohejing Hi-Tech Park, Pujiang, Shanghai, the company is at the forefront of innovation in this area. The company was founded in August 2018 and is currently a national high-tech enterprise, a science and technology-based small and medium-sized enterprise (SME) of the Ministry of Science and Technology (MOST), and has been awarded the Shanghai 2021 Innovation Funding Support for Science and Technology-Based SMEs, among other honors.

Since its establishment, the company has made rapid progress in the direction of research and development, and currently owns 13 core invention patents and 23 software copyrights in the direction of donor-derived free DNA (ddcfDNA) detection. In 2019 and 2020, six collaborative research results on ddcfDNA with domestic transplantation centers were invited to give oral presentations at the American Transplant Congress (ATC), the European Organ Transplant Congress (ESOT), and the International Organ Transplant Congress (TTS). In the past two years, we have published 18 articles on ddcfDNA, including 14 SCI articles.

At present, the company has completed the testing of 10,000+ ddcfDNA samples and has built the largest ddcfDNA gene database for organ transplantation in China. The company will continue to promote the precision of postoperative testing for Chinese transplant patients, providing comprehensive and accurate molecular-level information for each patient and assisting doctors in precise treatment.

Products and services
Donor-derived cfDNA Testing in Kidney Tranplant

Non-invasive Donor's HLA Typing

PymiR Score Testing

Methylation of Urine cfDNA Testing to Trace Renal Cell Origin

Hereditary Kidney Disease Gene Testing

Post Liver Transplant Genetic Test

Pathogenic Microorganism Infection Test

Heart and Lung Transplantation

Graft-versus-host disease

Immunosuppressant Drug Metabolism

Research Services

Investigations

 * Cell-Free Mitochondrial DNA: An Upcoming Non-Invasive Tool for Diagnosis of BK Polyomavirus-Associated Nephropathy
 * Differentiation between lung allograft rejection and infection using donor-derived cell-free DNA and pathogen detection by metagenomic next-generation sequencing
 * Application of plasma donor-derived cell free DNA for lung allograft rejection diagnosis in lung transplant recipients
 * Using Both Plasma and Urine Donor-Derived Cell-Free DNA to Identify Various Renal Allograft Injuries
 * Analysis of cell-free fetal DNA in 16,843 pregnant women from a single center in China using targeted sequencing approach
 * Plasma Donor-Derived Cell-Free DNA Levels Are Associated With the Inflammatory Burden and Macrophage Extracellular Trap Activity in Renal Allografts
 * Dynamics of Donor-Derived Cell-Free DNA at the Early Phase After Pediatric Kidney Transplantation: A Prospective Cohort Study
 * Donor-derived cell-free DNA: An independent biomarker in kidney transplant patients with antibody-mediated rejection
 * Urinary donor-derived cell-free DNA as a non-invasive biomarker for BK polyomavirus-associated nephropathy
 * A novel urine cell-free DNA preservation solution and its application in kidney transplantation
 * The role of donor-derived cell-free DNA in the detection of renal allograft injury
 * Preliminary clinical experience applying donor-derived cell-free DNA to discern rejection in pediatric liver transplant recipients
 * Prognostic value of the donor-derived cell-free DNA assay in acute renal rejection therapy: A prospective cohort study
 * Urine Donor-Derived Cell-Free DNA Helps Discriminate BK Polyomavirus-Associated Nephropathy in Kidney Transplant Recipients With BK Polyomavirus Infection