User:RNAPolymerase21/Sinapaldehyde

In macrophages that had been activated by lipopolysaccharide,

-SNAH decreases inflammation by disrupting iNOS and COX-2 enzyme function and thereby stopping NO creation.

-SNAH diminished inflammation-producing molecules such as: TNF-α, and IL-6.

-class of methoxyphenols

-found in plants: Senra incan Ailanthus altissima, Eucalyptus globulus, Oryza sativa  Dendropanax dentiger, and Populus tomentosa

-Antibacterial to oral bacteria Streptococcus pyogenes, Streptococcus mitis, and Streptococcus mutans

References

Meerungrueang W., Panichayupakaranant P. Antimicrobial activities of some Thai traditional medical longevity formulations from plants and antibacterial compounds from Ficus foveolata. Pharm. Biol. 2014;52:1104–1109. doi: 10.3109/13880209.2013.877493.

Farah M., Samuelsson G. Pharmacologically Active Phenylpropanoids from Senra incana. Planta Medica. 1992;58:14–18. doi: 10.1055/s-2006-961380.

Kim H., Lee J.S., Sezirahiga J., Kwon J., Jeong M., Lee D., Choi J.-H., Jang D.S. A New Canthinone-Type Alkaloid Isolated from Ailanthus altissima Swingle. Molecules. 2016;21:642. doi: 10.3390/molecules21050642.

Conde E., Cadahia E., Garcia-Vallejo M.C., Tomas-Barberan F. Low molecular weight polyphenols in wood and bark of Eucalyptus globulus. Wood Fiber Sci. 2007;27:379–383.

Koshiba T., Hirose N., Mukai M., Yamamura M., Hattori T., Suzuki S., Sakamoto M., Umezawa T. Characterization of 5-Hydroxyconiferaldehyde O-Methyltransferase in Oryza sativa. Plant Biotechnol. 2013;30:157–167. doi: 10.5511/plantbiotechnology.13.0219a.

Zheng L.-P., He Z.-G., Wu Z.-J., Zhang C. Chemical constituents from Dendropanax dentiger. Chem. Nat. Compd. 2012;48:883–885. doi: 10.1007/s10600-012-0411-1.

Van Acker R., Déjardin A., Desmet S., Hoengenaert L., Vanholme R., Morreel K., Laurans F., Kim H., Santoro N., Foster C., et al. Different Routes for Conifer- and Sinapaldehyde and Higher Saccharification upon Deficiency in the Dehydrogenase CAD1. Plant Physiol. 2017;175:1018–1039. doi: 10.1104/pp.17.00834.

Baek, Seung-Hwa, et al. “Anti-Inflammatory Activity and ROS Regulation Effect of Sinapaldehyde in LPS-Stimulated RAW 264.7 Macrophages.” Molecules, vol. 25, no. 18, Sept. 2020, p. 4089. DOI.org (Crossref), https://doi.org/10.3390/molecules25184089.