User:RResearcher/sandbox

Welcome to your sandbox!

Link to Project Resource Page
Project Homepage and Resources

Practice Editing Here (Nov 15th in-class Wiki session work)
Practice: TTR
 * This is a place to practice clicking the "edit" button and practice adding references (via the citation button).
 * Edit #1: Amyloidosis
 * Edit #2:

For example, in ATTR amyloidosis the fibrils originate from TTR. In AL amyloidosis, the misfolded protein originates from an immunoglobulin heavy or light chain fragment that can aggregate in any organ except the central nervous system.

Task:


 * 1) Find a peer-reviewed journal article on PubMed. Practice inserting your citation in the above space using the "cite" tool
 * 2) Choose one "B-level" medical article on Wikipedia from the following list: https://wp1.openzim.org/#/project/Medicine/articles?quality=B-Class&importance=High-Class
 * 3) Practice editing live on Wikipedia by finding a typo in the text or improving the clarity/readability of a sentence by adjusting a few words in a sentence.

Proposed changes:

 * 1) Add the following two lines to the Pathogenesis section, after the first sentence of the last paragraph: The beta-sheet form of amyloid is proteolysis-resistant, meaning it can not be degraded or broken down. As a result, amyloid deposits into the body’s extracellular space.
 * 2) Add the following lines to the Pathogenesis section, after the last sentence of the last paragraph: For example, in ATTR amyloidosis the fibrils originate from TTR. In AL amyloidosis, the misfolded protein originates from an immunoglobulin heavy or light chain fragment that can aggregate in any organ except the central nervous system.

Rationale for proposed changes:
The first change is necessary because the existing Wikipedia article mentions that amyloid forms into beta-sheet structures. However, it doesn’t expand on the significance of the beta-sheet form. Using the new reference, we highlighted that amyloid forms aggregates because this beta-sheet form is not degradable.

The second change is necessary because the pathogenesis section does not currently refer to the most common types of amyloidosis or which systems are most commonly affected. With the additional lines, the two most common types are introduced, providing concrete examples of affected systems to the more general description already given in the article.

The information for both changes originate from the following source: Gertz, M. A., & Dispenzieri, A. (2020). Systemic Amyloidosis Recognition, Prognosis, and Therapy: A Systematic Review. JAMA, 324(1), 79–89. https://doi.org/10.1001/jama.2020.5493.

Many of the references used in this section are >5 years old warranting a need for updating. The reference used for this addition is a systematic review from 2020, thus providing more up to date information. This source was found via a simple PubMed search for “amyloidosis pathogenesis”, with the search set to a timeframe within 5 years and a publication type of systematic review. It is shared by the major medical authority, JAMA; and there seem to be no conflicts of interest. As such, it fulfills Wikipedia’s reliable medical sources (MEDRS) criteria.

There was no controversy over suggested changes primarily because they provide factual unbiased information, use common language, and do not infringe on other sections.

Critique of sources:
Some identified limitations or potential sources of bias for the reference used for this suggested addition include:


 * 1) The article is authored by one clinical MD and one scientist MD, both from the same institution. This may create a narrowed perspective compared to an article authored by individuals from various institutions.
 * 2) Both authors report that a portion of their funding originated from pharmaceutical companies which has the potential to sway the outcome.
 * 3) The literature search was completed by a single medical librarian which may cause a limit or bias to which articles were considered for inclusion.
 * 4) Only primary sources written in English were included, thus data was limited to English speaking authors and/or publications. This may limit the perspective of the article and effects on amyloidosis in differing parts of the world.

These limitations were taken into account when suggesting the additional lines as they were kept factual and did not speak to specific treatment modalities (medication) or incidence of amyloidosis in specific areas. It was considered a strength that the authors came from a clinical and research background, thus increasing the likelihood that conclusions were both valid and clinically relevant.

Post on Talk Page:
Done



What to post on the Wikipedia article talk page (part of assignment 3)

 * This will also be covered on Nov 15th in class. Your group should use the below template to share an outline of your proposed improvements (including your new wording and citations). Article talk pages are not places to share your assignment answers. The Wikipedia community will be more interested in viewing your exact article improvement suggestions including where you plan to improve the article (which section), what wording you suggest, and the exact citation (Note: all citations must meet WP:MEDRS)
 * You will not be able to paste citations directly from your sandbox to talk pages (unless you are interested in editing/learning Wiki-code in the "source editing" mode). We suggest re-adding your citations on the talk page manually (using the cite button and populating the citation by pasting in the DOI, website, or PMID). You will have to repeat this process yet again when you edit the actual article live.
 * Talk Page Template: CARL Medical Editing Initiative/Fall 2021/Talk Page Template