User:Rafikragheb

'''Dr. Rafik Ragheb (Clinical Biochemist/ Clinical Scientist) completed his undergraduate studies at Ain Shams University, where he earned a Bachelor of Science degree in Biochemistry. He attended the school of graduate studies at both Ain shams university (Egypt) and University of Toronto (Canada) and completed his doctorate training in Biochemistry. Dr. Ragheb then pursued his career in Clinical Biochemistry at both the academic, diagnostic/clinical and industrial levels. His research interest includes the study of ``Mechanisms of fatty acid induced insulin resistance in muscles and liver``. His current reserach interest is focused on the cellular and molecular mechanisms by which insulin resistance syndrome, inflammation and immunoregulation contribute to metabolic syndrome and the pathophysiology of Type II Diabetes.'''

http://ca.linkedin.com/pub/rafik-dr-ragheb/25/b51/156

PUBLICATIONS:

1. Ragheb R., et. al. Mechanisms of Fatty Acid-Induced Insulin Resistance in Muscle and Liver. J Diabetes Metab (2011) 2:127. doi:10.4172/2155-6156.1000127

2. Ragheb R., et. al. Free fatty Acids - induced muscle insulin resistance and glucose uptake dysfunction: Evidence for PKC activation and oxidative stress activated signaling pathways. Biochem Biophys Res Commun. (2009). 389 (2), 211-216.

3. Ragheb R., et. al. Prolonged Treatment with free fatty acids has post receptor effect in hepatic insulin resistance: Evidence that free fatty acids, oleate and palmitate have insignificant effect on the insulin receptor beta in vivo and ex vivo primary hepatocytes. Biochemistry Insights. (2009) 2: 29-36.

4. Ragheb R., et. al. Links between enhanced Fatty Acid Flux, Protein Kinase C and NFB Activation, and ApoB-Lipoprotein Production in the Fructose Fed Hamster Model of Insulin Resistance. Biochem Biophys Res Commun. (2008) 23; 370(1):134-9.

5.	Huang S, Qu LK, Cuddihy AR, Ragheb R, Taya Y, Koromilas AE. Protein kinase inhibitor 2-aminopurine overrides multiple genotoxic stress-induced cellular pathways to promote cell survival. Oncogene. 2003 Jun 12; 22 (24):3721-33.

6.	Rafik Ragheb, S. Abrahams, R. Beecroft, J. Hu, J. Ni, V. Ramakrishna, G. Yu, and R. M. Gorczynski. Preparation and functional properties of monoclonal antibodies to human, mouse and rat OX2. Immunol. Lett. 68 (1999) 311-315.

7.	Zeinab Z.El Dardery, Irene R.Iskander, Amina M. Medhat, Waheed M.El Harrizy and Rafik Ragheb. Effect of Extracorporeal Shock Wave Lithotripsy (ESWL) on renal function. J Biomed Sciences and Therapeutics (Egypt). 1994, Oct (6): 70 – 79.

ABSTRACTS:

•	Rafik Ragheb, et.al., Evidence for a role of oxidative stress activated signaling pathways in mediating muscle insulin resistance and glucose uptake dysfunction. (7th Annual World Congress on the Insulin Resistance Syndrome, San Francisco 2009 - USA) Diabetes & Vascular Disease Research. Volume 4 Issue 3, 2009UK

•	Rafik Ragheb, et.al.., Prolonged treatment with free fatty acids (FFA) has post receptor effect in hepatic insulin resistance: evidence that fatty acids, oleate and palmitate have no effect on the insulin receptor beta (IR-β) in vivo and ex vivo primary hepatocytes (6th Annual World Congress on the Insulin Resistance Syndrome, Los Angles 2008 - USA) - Diabetes & Vascular Disease Research. Volume 4 Issue 3, 2008UK

•	Rafik Ragheb, et.al., Different Free fatty acids (FFAs) – induced serine 307 phosphorylation of IRS-1 as a novel mechanism for skeletal muscle insulin resistance.(5th Annual World Congress on Insulin Resistance Syndrome, Boston, USA-2007 - Diabetes & Vascular Disease Research. Volume 4 Issue 3, 2007UK

•	Rafik Ragheb, et. al., Free fatty acids - induced PKC and NFB activation as a mechanism for both insulin resistance and dyslipidemia in the fructose fed hamster model of insulin resistance.(5th Annual World Congress on Insulin Resistance Syndrome, Boston, USA-2007)- Diabetes & Vascular Disease Research. Volume 4 Issue 3, 2007UK •	Rafik Ragheb, Amina M. Medhat, Gamila M. Shanab, Dina, M. Seoudi, Fantus, I.G., Adeli K. Free fatty acids (FFAs) – induced PKC and NFB activation, two key events in two different models for insulin resistance, the skeletal muscle and liver. (4th Annual World Congress on Insulin Resistance Syndrome, Nevada, USA)-Diabetes & VascularDiseaseResearch.Volume3Issue2,2006UK .(http://www.insulinresistance.us/view.php/ItemID=222).

•	Rafik Ragheb, Khosrow Adeli and George Fantus. Evidence for fatty acid-induced insulin resistance in a cultured muscle cell line, C2C12: Differential effects of fatty acid species on insulin signaling pathways (International Congress of Biochemistry and Molecular Biology). Molecular & Cellular Proteomics 2:642-670, 2003 – Montreal. •	Ragheb, R., Chong, T.M., Naples, M., Fantus I.G., Adeli K. Tissue-specific Effect of Fatty Acids on Insulin Sensitivity: Evidence that fatty acids, oleate and palmitate, induce muscle insulin resistance but have no effect on hepatic insulin sensitivity. University Health Network and Hospital for Sick Children, University of Toronto. Canadian Lipoprotein Conference, 2003, Toronto, Canada.

•	Rafik Ragheb, Khosrow Adeli and George Fantus. Mechanisms of Fatty Acid - Induced Insulin Resistant In a Cultured Muscle Cell Line, C2C12: Evidence For Differential Effect Of Oleate And Palmitate On insulin Signaling Pathway. XIX International American Congress of Cardiology/ XIX l'InterAmerican Congress of Cardiology October 24-29, 2003, Toronto, Ontario / 24-29 October 2003, Toronto, Ontario. Cardiovascular Pathology, May 2004 (Vol. 13, Issue3 (Supplement).

•	Gorczynski RM, Chen Z, Kai Y, Lei J, Ragheb R. Persistent expression of OX-2 is necessary for renal allograft survival. FASEB JOURNAL (Abstract). 14 (6): A1069-A1069 Suppl. S APR 20 2000.

•	D.E.C.Cole, L.A.Rubin, G.A.Hawker, R. Ragheb, R.Vieth, and J.-S.Brunet. Effects of population structure on vitamin D receptor (VDR) polymorphism frequencies and their implications for genetic analysis of metabolic bone disease. Am J Bone and Min Res. 11:S482., 1996.

•	Rubin LA, Cole DEC, Hawker GA, Ragheb R, Vieth R, Brunet JS. Effects of population structure on vitamin D receptor polymorphism frequencies and their implications for genetic analysis of metabolic bone disease (Abstract). Arthritis AND Rheumatism. 39 (9): 673-673 Suppl. S SEP 1996.