User:Rameshbio2007

Code No: R05322301 Set No. 1 III B.Tech II Semester Regular Examinations, Apr/May 2008 BIO-INFORMATICS (Bio-Technology) Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks ⋆ ⋆ ⋆ ⋆ ⋆ 1. What is Bioinformatics? Describe its scope in modern biology? [16] 2. Describe the following: (a) Sequence Homology (b) Di�erences between orthologs and paralogs. [8+8] 3. Describe the following: (a) Physical mapping of DNA (b) Genetic mapping of DNA. [8+8] 4. What is Block Substitution Matrices (BLOSUM)? Describe them in detail? [16] 5. Discuss about the molecular modeling databases and their applications in bioinfor- matics. [16] 6. Discuss the applications of bioinformatics tools available in Swissprot. [16] 7. Describe in brief about KEGG and state how it is useful in research. [16] 8. How would you construct phylogenetic trees using clustal programs. [16] ⋆ ⋆ ⋆ ⋆ ⋆ 1 of 1 Code No: R05322301 Set No. 2 III B.Tech II Semester Regular Examinations, Apr/May 2008 BIO-INFORMATICS (Bio-Technology) Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks ⋆ ⋆ ⋆ ⋆ ⋆ 1. Write short notes on the following: (a) Domain and Domain name (b) Modem. [8+8] 2. Describe the Charles Darwin Contribution to Evolutionary Theory? [16] 3. Describe the steps involved in sequence assembly? [16] 4. Describe the steps in Needlemen-Wunsch algorithm for Global sequence alignment? [16] 5. How can you search and retrieve information of unknown gene from World Wide Web. Explain thesteps involved with one example. [16] 6. What are secondary databases? Discuss the major secondary databases you have studied. [16] 7. Describe in brief about BRENDA and state its applications in bioinformatics. [16] 8. What is dynamic programming method. Explain with an example. [16] ⋆ ⋆ ⋆ ⋆ ⋆ 1 of 1 Code No: R05322301 Set No. 3 III B.Tech II Semester Regular Examinations, Apr/May 2008 BIO-INFORMATICS (Bio-Technology) Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks ⋆ ⋆ ⋆ ⋆ ⋆ 1. Describe the following: (a) Uniform Resource Locator (URL) (b) Role of Internet in Bioinformatics. [8+8] 2. Describe the Richard Owen’s Contribution to Evolutionary Theory? [16] 3. (a) What are the goals of sequence analysis. (b) Importance of C-DNA libraries. [8+8] 4. Describe the following: (a) Importance of GAPs and GAP penalties in sequence alignment (b) Edit distance of two strings. [8+8] 5. Define Database? Briefly explain the biological databases? [16] 6. Discuss briefly the search and analysis tools available in PIR and state their appli- cations. [16] 7. Describe in brief about the tools available in ERGO. [16] 8. What is multiple sequence alignment. Explain with an example. [16] ⋆ ⋆ ⋆ ⋆ ⋆ 1 of 1 Code No: R05322301 Set No. 4 III B.Tech II Semester Regular Examinations, Apr/May 2008 BIO-INFORMATICS (Bio-Technology) Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks ⋆ ⋆ ⋆ ⋆ ⋆ 1. Describe the following: (a) Uniform Resource Locator (URL) (b) Role of Internet in Bioinformatics. [8+8] 2. Describe the Richard Owen’s Contribution to Evolutionary Theory? [16] 3. Describe the following: (a) Physical mapping of DNA (b) Genetic mapping of DNA. [8+8] 4. What is sequence alignment? Describe the significance of sequence alignment in detail? [16] 5. Discuss about the bioinformatics tools that are available at EMBL website. [16] 6. Discuss the applications of bioinformatics tools available in Swissprot. [16] 7. Describe in brief about BRENDA and how it is useful in research. [16] 8. What is the di�erence between pair-wise and multiple alignments illustrate with suitable examples. [16] ⋆ ⋆ ⋆ ⋆ ⋆ 1 of 1