User:Rampreddy/Synaptic gating

Wikipedia Proposal: Synaptic gating
Danny Baush, Ram Reddy, Abby Stemper

General definition:
Synaptic gating is the ability of neural circuits to "gate" inputs by either suppressing or facilitating specific synaptic activity. Selective inhibition of certain synapses has been studied thoroughly (see Gate theory of pain); however, recent studies have supported the existence of permissively gated synaptic transmission.

Synaptic gating and neuromodulation

 * Requires a “gatekeeper” (‘gating involves the momentary control of synaptic efficacy by a neuron other than the neuron being gated’)
 * Long term potentiation, synaptic facilitation and augmentation, though forms of neuromodulation, are not considered gating mechanisms

Suppressive gating (selective inhibition)

 * Primary afferent depolarization (PAD)
 * Sensory gating (selective attention)

Permissive gating

 * Intrinsic neuromodulation
 * Presynaptic receptor facilitation
 * Voltage facilitation

Synaptic gating and disease

 * ADHD and anxiety: theory of comorbidity
 * Parkinsons disease

Division of workload:
We have decided to schedule times that we can all meet to work together on the various parts of this project. We think that this is the best way for all of us to discuss and understand fully the topic so that we can create a cohesive article.