User:RawansAljohani/sandbox

I evaluated RNA splicing article and the article is helpful and resources are reliable. The History of TFHII: ( from 1TFIIH: when transcription met DNA repair) DNA repair)

Before TFHII identified it has a several names : this factor first in 1989 isolated from liver of rat known that time as factor transcription delta it also, isolated from cancer cell known that time as Basic transcription factor 2, Also, it is isolated from yeast known transcription factor B. Finally, in 1992 known as  TFHII.

What are the component of TFHII: ( from 2The essential and multifunctional TFIIH complex) (Molecular Structure of Human TFIIH) The TFHII contains of two main pieces the core with is the core XPB has these subunits p62, p52, p44, p34 and p8 and CAK composed of CDK7, cyclin H and MAT1. The unit that join the core to the CAK called XPD

General function of it 1. Initiation transcription of protein- coding gene 2. DNA nucleotide repairing (NER)

Mechanism of TFHII repairing DNA damaged sequence RAWAN S ALJOHANI RawansAljohani (talk) 18:23, 14 October 2018 (UTC)