User:Recoorion/OLES2129/draft

Article Title:

Neural Transplantation (https://en.wikipedia.org/wiki/User:Recoorion/Neural_Transplantation)

Associated WikiProjects

https://en.wikipedia.org/wiki/Wikipedia:WikiProject_Cognitive_science

https://en.wikipedia.org/wiki/Wikipedia:WikiProject_Medicine/Neurology_task_force

Description

Neural transplantation is a medical procedure that involves the transplantation of cells and neural tissues into an organism’s CNS (Central Nervous System). Research in to this area has been conducted over the past 40 or so years, since the 1970s. In animal experiments, it has been shown to be able to replace lost neurons, restore function, and promote brain self-repair. However, clinical trials with humans while showing promise, particularly with those suffering from Parkinson’s disease, has also had inconsistencies in results, and is still in being researched, with the hopes of potentially bringing it to clinical therapy.

Titles of Sections


 * History (brief description of the history of neural transplantation)
 * Clinical uses
 * Issues (issues surrounding the use of neural transplantation as a medical procedure)
 * Scientific
 * Ethical
 * Future

Sources and Annotations

Mehta, V., Spears, J., & Mendez, I. (1997). Neural Transplantation in Parkinsons Disease. Canadian Journal of Neurological Sciences / Journal Canadien Des Sciences Neurologiques, 24(04), 292-301. doi:10.1017/s0317167100032959

This report provides insight into some of the history of neural transplantation, specifically for the treatment of Parkinson’s Disease through animal experimentation.

Björklund, A., & Lindvall, O. (2000). Cell replacement therapies for central nervous system disorders. Nature Neuroscience, 3(6), 537-544. doi:10.1038/75705

This report compares the research and results of neural transplantation with regards to Parkinson’s disease, Huntington’s disease, epilepsy, and strokes. It also highlights the efficacy of using neural transplantation within these areas, and how some are shown to be effective, while others lack proper pre-clinical research.

Borlongan, C. V., Sanberg, P. R., & Freeman, T. B. (1999). Neural transplantation for neurodegenerative disorders. The Lancet, 353. doi:10.1016/s0140-6736(99)90229-5

This article provides information on how neural transplantation has helped with the treatment to certain neurodegenerative disorders, and the research into them (Parkinson’s disease, and Huntington’s disease).

Piccini, P., Pavese, N., Hagell, P., Reimer, J., Björklund, A., Oertel, W. H.,. . . Lindvall, O. (2005). Factors affecting the clinical outcome after neural transplantation in Parkinsons disease. Brain, 128(12), 2977-2986. doi:10.1093/brain/awh649

This report provides insight into the possible factors that can affect the outcome of neural transplantation clinically. This report will be particularly useful in writing the clinical uses and issues areas of the article.

Gash, D. M., & Sladek, J. R. (1989). Neural Transplantation: Problems and Prospects—Where Do We Go From Here? Mayo Clinic Proceedings, 64(3), 363-367. doi:10.1016/s0025-6196(12)65259-8

This report discusses the results of the implantation of adrenal autografts in seven patients as a treatment for Parkinson's disease, as well as a discussion on the issues surrounding neural transplantation and what may come of it.