User:Redeemer079/Sandbox1

Role in DNA repair
Since DNA polymerase delta is involved in resynthesis of excised damaged DNA strands during DNA repair, PCNA is important for both DNA synthesis and DNA repair. PCNA is also involved in the switch to DNA damage bypass translesion synthesis:


 * Mismatch repair (MMR)


 * Base excision repair (BER)


 * Nucleotide excision repair (NER)

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 * Chromatin assembly


 * Epigenetic inheritance and chromatin remodeling


 * Sister-Chromatid cohesion


 * Cell-Cycle control and survival

PCNA-binding proteins
DNA polymerases •  Clamp loader  •  Flap endonuclease  •  DNA ligase  •  Topoisomerase  •  Replication licensing factor  •  E3 ubiquitin ligases  •  E2 SUMO-conjugating enzyme  •  Helicases, ATPases  •  Mismatch repair enzymes  •  Base excision repair enzymes  •  Nucleotide excision repair enzyme  •  Poly ADP ribose polymerase  •  Histone chaperone  •  Chromatin remodeling factor  •  Histone acetyltransferase  •  Histone deacetyltransferase  •  DNA methyltransferase  •  Sister-chromatid cohesion factors  •  Protein kinases  •  Cell-cycle regulators  •  Apoptotic factors

for details see