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= Hakho Lee = Hakho Lee (born November 5, 1973, in Seoul, South Korea) is an American scientist. He is a Professor in Radiology at Harvard Medical School, the director of the Biomedical Engineering Program at the Center for Systems Biology, Massachusetts General Hospital (MGH), Hostetter MGH Research Scholar, and a core faculty of the MGH Institute for Innovation in Imaging (i3).

Education
Lee received his B.S. degree in Physics from Seoul National University in 1998, followed by the completion of his Ph.D. in Physics from Harvard University in 2005. Subsequently, he was a postdoctoral research fellow at MGH, where he worked with Professor Ralph Weissleder on advancing microNMR technologies for clinical diagnostics. He became a professor at Harvard Medical School in 2023.

Research
Dr. Lee's research centers on the development of innovative biomedical sensors for real-world clinical applications. By integrating key concepts in nanomaterials, biophysics, electronics, and computational science, he designs robust and practical engineering solutions for unmet medical needs. Notable examples include a keychain-sized food-allergen identifier, an ultrafast plasmonic PCR system, an onsite THC test , and CRISPR-based nucleic acid sensors.

Dr. Lee is a pioneer in the field of liquid biopsy, specifically focusing on extracellular vesicles (EVs) as circulating biomarkers. His early research established that cancer-specific EVs are present in the blood of glioblastoma (GBM) patients, offering insights for diagnosis and treatment monitoring.

His lab has developed a range of innovative analytical tools to advance EV research, including a dual-column device for EV enrichment, microfluidic platforms for EV RNA analysis , and electrical/optical sensors for EV protein detection. Notably, his nanoplasmonics technology was recognized as one of the "greatest hits" in 20 years of Nature Biotechnology biomedical research. He is currently exploring platforms for multidimensional single-EV profiling. Applying these new technologies, Dr. Lee's lab is expanding the clinical utility of EVs in cancer care, with potential applications in early diagnosis, prognosis , and treatment decisions.