User:RegOH/Bio460Sandbox

This is the project sandbox for the Bio 460 assignment by RegOH and Emileemagnusen

Sirtuin Genes
This article has been rated as a start page. The layout of the page is correct, but language of the page is very technical and difficult to understand. It provides unnecessary detail, and most subsections are underdeveloped. The page has a good list of references. On the talk page, which has very few comments, it was suggested that the article, especially the opening sentences, should be understood by the average reader. I think the picture should also be changed. Again, the one on the article page is very technical and would not be easily understood. I think a picture that is easier to read or one that has more practical application should replace it.

Possible References
"The Yin-Yang of Sirtuins," by Andrew Dillion and Jefferey Kelly in Science: http://www.sciencemag.org.ezp.slu.edu/content/317/5837/461.full.pdf?sid=d7e674e0-0b60-4348-88dc-25e2049d997f

"Aging Genes: The Sirtuin Story Unravels," by Jennifer Couzin-Frankel in Science (2 December 2011): http://www.sciencemag.org.ezp.slu.edu/content/334/6060/1194.full.pdf?sid=d7e674e0-0b60-4348-88dc-25e2049d997f

Werner Syndrome
This article has been rated as a start page as well. The introduction is fairly choppy, lacking transition. There seems to be an abundance of references, but most of the sections and subsections are not developed. It is neutral in tone. However, it could benefit from additional illustrations and pictures. There is no discussion on the talk page other than a to-do list, which includes citations/edits, a picture with someone with Werner Syndrome, and copyedit. A picture of someone with Werner Syndrome would be helpful.

Possible References
"Werner Syndrome: A New Case Report," by Ajili et al. in Our Dermatology Online: http://eds.a.ebscohost.com.ezp.slu.edu/eds/pdfviewer/pdfviewer?vid=3&sid=ba30d584-2ad1-43bf-ab85-9b552cf76659@sessionmgr4002&hid=4203

"Werner Syndrome: A case report and review of literature," by Khan et al. in Journal of Pakistan Association of Dermatologists 2011;21 (4): 304-308: http://eds.a.ebscohost.com/eds/pdfviewer/pdfviewer?vid=4&sid=ba30d584-2ad1-43bf-ab85-9b552cf76659%40sessionmgr4002&hid=4203

Autophagy
This article is rated as a "Start." The introduction could be less technical, better pictures could be used, and most of the sections within the article could be greatly expanded upon. The talk page doesn't show a lot of very recent activity. In some places, the tone could be more neutral and the writing could be better.

Possible References
Cuervo AM, Bergamini E, Brunk UT, Dröge W, Ffrench M, Terman A. Autophagy and Aging: The Importance of Maintaining "Clean" Cells. Autophagy 2005; 1:131 - 140; ; http://dx.doi.org/10.4161/auto.1.3.2017

Feng W, Chang C, Luo D, Su H, Yu S, Hua W, Chen Z, Hu H, Liu W. Dissection of autophagy in human platelets. Autophagy 2014; 10:76 - 85;

García-Macia M, Sierra V, Palanca A, Vega-Naredo I, de Gonzalo-Calvo D, Rodríguez-González S, Oliván M, Coto-Montes A. Autophagy during beef aging. Autophagy 2014; 10:137 - 143; ; http://dx.doi.org/10.4161/auto.26659

Chromatin remodeling
This article is rated as a "Stub." The language is too technical throughout the article. The introduction could be expanded. It has an "overview" section which probably should just be part of the introduction. The "modifications" section is just a list and could definitely be expanded upon. Most of the sections should probably be reorganized and expanded upon. The talk page is empty.

Possible References
McKittrick, Erin, Gafken, Philip R, Ahmad, Kami, Henikoff, Steven. Histone H3.3 is enriched in covalent modifications associated with active chromatin. PNAS 2004; 101:1525-1530. doi: 10.1073/pnas.0308092100

Clapier, Cedric R, and Cairns, Bradley R. The Biology of Chromatin Remodeling Complexes. Annual Review of Biochemistry 2009; 78:273-304. DOI: 10.1146/annurev.biochem.77.062706.153223

Secondary Sources about Werner Syndrome

 * This article provides an overview of what Werner Syndrome is, what the symptoms are, what causes it, and what other diseases are associated.
 * This article contains more detailed information about the WRN protein.
 * This article gives a good overview of the symptoms and associated disorders of Werner Syndrome. It also discusses the distribution of Werner Syndrome, which has a much higher rate of incidence in Japan than anywhere else.