User:RepelCorona/Anserine

Anserine is a derivative of carnosine, which had been methylated.

A study observing the effect of anserine diet on blood clearance and food absorption concluded that the data showed an ephemeral anserine level peak in blood after consumption of anserine, followed by a prolonged, high level of methylhistidine. This indicates rapid absorption and clearing of anserine because anserine is catabolized into methylhistidine and alanine by enzyme found in blood. Then, a succeeding experiment was laid out to test the difference between the first group of people consuming extracted anserine and the latter consuming anserine as found in food. In these two groups, while the concentrations of L-histidine-related compound varied depending on the amount of anserine consumed, the absorption level patterns in blood were congruous, proving that anserine taken in food equally helps rapid absorption of food compared to when extracted anserine is taken alone.

To arrive at this conclusion, scientists stained pericytes from mouse and found that anserine treated mouse had greater surface area of cells than those that were not treated with anserine. The greater area of pericyte is commensurate with improved memory because pericyte warp around brain capillary to control blood flow and gate cells from neurotoxin, blocking inflammation. Furthermore, they performed Morris Water Maze tests on mouse and found that anserine treated mouse had overall better spatial memory. The effects of anserine and carnosine were also observed in humans; One study done with 84 elders in Tokyo found that elders who took 500mg of anserine and carnonsine for one year showed more blood flow in the prefrontal cortex through the MRI.

There has also been study revealing that free N-terminal of histidine on anserine and carnosine protect against zinc-caused neurotoxicity and regulate Arc pathway in which Arc protein is used to produce dendrite protein for connecting nerve cells.