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Lilith's Brood is a collection of three works by Octavia Butler. The three volumes of this science fiction series (Dawn, Adulthood Rites, and Imago) were previously collected in the now out of print volume, Xenogenesis. The collection was first published under the current title of Lilith's Brood in 2000.

Synopsis
In the first novel in the trilogy, Dawn published in 1987. The story begins after A group of extremists obtained nuclear weapons and their actions resulted in a terrible nuclear war that left the earth uninhabitable. Humans are all but extinct. The few survivors are plucked from the surface of their dying world by an alien race, the oankali. The title character Lilith (a black human female) awakens centuries later from stasis on an Oankali ship. She meets her saviors/captors and is repulsed by their alienness. The oankali don’t have eyes, or ears, or noses, but sensory tentacles over their entire bodies with which they can perceive the world much better than a human can. Stranger still the oankali have three genders; male, female; and ooloi. All oankali have the ability to perceive biochemistry down to a genetic level but the ooloi have the ability to directly manipulate genetic material. Ooloi can mutate and “evolve” any living thing they touch and build offspring gene by gene using the genetic material from their male and female mates. Despite their differences the ooloi oankali are strangely alluring, sexually arousing even while being visually repulsive. The oankali have made earth habitable and want Lilith's help in training humans to survive on earth without human technology. In exchange the oankali want to interbreed with the humans to create a new human-oankali hybrid race. This book focuses on the conflict between Lilith's desire to stay human and her loyalty to her species and her desire to survive at any cost.

The second book, Adulthood Rites, published in 1988, takes place years after the end of Dawn. Humans and oankali live together on earth though everything is not peaceful. Some humans have accepted the bargain and live with the oankali and give birth to hybrid children called constructs. Others however have refused the bargain and live in separate, all human, villages. The ooloi have made all humans infertile so the only children born are the ones made with ooloi intervention. This creates a great deal of tension and strain as the humans see themselves being outbreed by the oankali-human constructs. Desperate humans often steal human looking construct children to raise as their own. The main character of the second book Akin is the first male construct born to a human mother. Akin has more human in him than any construct before him. This book focuses on Akin’s struggle with his human and his oankali natures. As a human he understands the desire to fight for the survival of humanity as an independent race. As an oankali he understands that the combination of the species is necessary and that humans would destroy themselves again if left alone.

The final book of the trilogy, Imago published in 1989, is the shortest. Imago shows the reader what has been hinted at for the last two books, the full potential of the new human-oankali hybrid species. The story is told from the prospective of Jodahs, the first ooloi construct. Through its unique heritage it has unlocked latent genetic potential of humans and oankali. This book brings a sense of completeness to the story by allowing the reader to understand the oankali better by understanding Jodahs.

Themes
Throughout the Xenogenesis series themes of sexuality, gender, race, and species are explored. The oankali believe that humans have an inevitable self-destructive conflict between their high intelligence and their hierarchical natures. According to the oankali this is what caused the war that almost ended the human race and this is why they cannot leave the humans alone. Lilith and the oankali-human hybrids are constantly battling with this inner conflict. According to TOR.com's Erikia Nelson  the trilogy parallels the story of African slaves in america and the conflict that latter generations of African Americans feel regarding their integration into american society. The human-oankali hybrids feel that they have somehow betrayed their human side by integrating into oankali society but at the same time because of the vast power imbalance they never really had another viable option. This theme is again acknowledged by Timothy Laurie of the University of Melbourn who contrasts the common nurturing image of womanhood with Lilith's drive to survive at any cost, even if it mean sacrificing some of what she believes it means to be human. The series also draws upon elements of the myth of Lilith, the first wife of Adam.

In addition to the social themes the possible results of developing genetic science and biologically based technology are shown by the oankali's genetic mastery. Joan Slonczewski, a biologist, published a review of the series in which she discusses the biological implications of the ooloi and how they can, through genetic engineering, achieve positive effects from "bad" genes such as a predisposition for cancer.

Reception
Each of the three books originally was nominated for a Locus Science Fiction Award in the year it was published (1987, 1988 and 1989) though none of the books won the award.