User:Richarnj/sandbox

Welcome to my main sandbox page.

Wikipedia is an encyclopedia
Wikipedia is NOT a dictionary, newspaper, list of sources, or publisher of personal research, but it IS a combination of many informative sources to provide general information on a topic backed up by sources which can be consulted for further information beyond that of the encyclopedia.

Wikipedia is written from a neutral point of view
Wikipedia strives to present ALL points of view without giving preference to any particular view. Articles are NOT a forum for debate and should only be present impartial, verifiable facts.

Wikipedia is free content that anyone can edit, use, modify, and distribute
ALL content is freely licensed to the public and therefore not owned by any individual. ALL content can be edited by any individual.

Editors should treat each other with respect and civility
There will often be disagreements between fellow editors; however, consensus should be sought through good faith and calm conversation.

Wikipedia does not have firm rules
Wikipedia only has general policies and guidelines allowing for evolution in interpretation. Mistakes can always be corrected, and edits should be made often and in good spirit.

Stub Class Articles
A stub class article is with what we will begin our project. These articles are extremely basic likely without any references. In many cases these pages are similar to a dictionary definition. In other cases they contain incomprehensible information that does not add to the value of the article despite the added length.

B Class and Good Articles
Our target end class for our project article is somewhere between a B-class and a good article. There are six criteria an article must meet to be considered B-class as outlined by the Wikipedia guidelines. Articles of this class must be reasonably well written in terms of style and grammar. The article must be well-structured covering all aspects of the topic and be verifiable with ample reliable references and inline citations. Figures, diagrams, charts, and other supporting information should be included as appropriate to improve understanding of the topic.

In order to improve an article from B-class to a good article, the article needs to approach a professional level. Good articles have very well written broad coverage of the topic that requires little to no prior knowledge of the subject. These articles contain plenty of references and inline citations to verify the articles content without any original research on the part of the reader. Images are used to enhance the content, but are included only with suitable captions, copyright status, and rationale as necessary. Good articles are approved as such by an official review.

RefTools Citation Practice
Demo cite from course page

Caffeine and Parkinson disease
Parkinson disease is a condition that generally manifests itself later in life showing symptoms including tremors, loss of motor control, loss of posture control, sleep disorders and depression. This symptoms are caused by the death of dopaminergic neurons resulting in emotional, memory, and motor control degradation. Early studies suggest that caffeine may provide protection for the dopaminergic neurons and improve motor control in patients allowing them to maintain their quality of life for a longer period of time.

Management of esophageal cancer
Esophageal cancer is one of the most deadly cancers in the US with 15210 deaths in 17990 cases in 2013. There are two types of esophageal cancer, one that begins in the squamous of flat cells lining the esophagus and adenocarcinoma which releases mucus from the esophageal cells. Integration of PET and CT scanning in the early stages may increase the success of treatment when combined with the traditional chemotherapy, radiation therapy, and esophagectomy. PET/CT may be able to detect metastatic disease that would otherwise go unnoticed in early stages therefore improving the chances that treatment will be successful.

Viral transformation outline
The following is an initial outline for proposed edits to the Viral transformation article.

Lead section
Simple overview answering the question, What is viral transformation? Basic information regarding applications of viral transformation.

Introduction
Slightly more in depth description of what viral transformation is and why it is important.

How do viruses prepare to transform other cells
Discussion of methods both in vitro and in vivo

How is a cell transformed once the vector enters the cell
Changes in the cell
 * Physiological
 * Biochemical
 * Genomic

Applications
Each application could have its own section given there is enough information to support it, such as personalized medicine, tumor reduction, and drug delivery.

Images
Not sure how useful some of these images will be but they are at least a start. Many of them are how viruses infect and kill cells.
 * https://en.wikipedia.org/wiki/File:Virus_Replication_large.svg
 * https://en.wikipedia.org/wiki/File:Ebola_Pathenogensis_path.svg
 * https://upload.wikimedia.org/wikipedia/commons/d/da/Making_of_a_DNA_vaccine.jpg
 * https://en.wikipedia.org/wiki/File:Life_Cycle_of_a_Retrovirus.svg
 * http://biosearch.berkeley.edu/image.php?img=images%2Fopensearch%2Fartid%3D1852297%26blobname%3D1743-422X-4-35-1.jpg&pmid=17397531&fig=1

Article refs

 * 1) Effect of transforming viruses on molecular mechanisms associated with cancer.
 * 2) Viral transformation for production of personalized type I interferons.
 * 3) Cell Transformation by RNA Viruses: An Overview
 * 4) Alteration of cell-surface proteins by viral transformation (Cell-surface proteins are altered during viral transformation, and ultimately it affects the rate of cell growth.)
 * 5) Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism of generating the transforming virus. (summary of the recombination techniques associated with the c-src gene to insert genes into the transforming virus)
 * 6) The DNA damage response in viral induced cellular transformation. (DNA damage response (genomic changes) that take place when a viral induced transformation occurs in oncogenesis)
 * 7) Epstein-Barr virus EBNA3C can disrupt multiple cell cycle checkpoints and induce nuclear division divorced from cytokinesis. (how EB virus induced transformation induced changes in the cell cycle (genomic changes))