User:Rithika23/sandbox

Chimerins have a high affinity for phorbol esters as well as diacyl glycerols. They are crucial to neuronal signal transduction mechanisms. Mutations in α-chi-merin are responsible for Duane retraction syndrome 2. Beta-chimerin (Rho GTPase-activating protein 3, 468aa) is found mostly in the brain and pancreas and expression is much reduced in malignant gliomas. Through their action on Rac, they lead to changes in cytoskeletal organization.