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Microfibrils are part of the hierarchy in the molecular assembly of biological fibers. During the assembly, mirofibrils exhibit a repeating stringed-beads pattern produced by the cross-linking of molecules forming a striated pattern described in its periodicity.

Fibrillin
Fibrillin microfibrils are found in connective tissues, mainly composed of fibrillin-1 and providing elasticity. In the formation of elastic fiber, fibrillin microfibrils guides the deposit of tropoelastin and remains in the outer layer of mature elastin fibers. The microfibril is also associated in cell communication. Formation of fibrillin microfibrils in the pericellular region affects the activity of a growth factor called TGFβ.

There is an increase in TGFβ activity associated with Marfan Syndrome due to the mutation of fibrillin-1.