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Wikipedia Project Proposal: Chromatolysis
Michele Kelley

General Definition
Chromatolysis is the disintegration of chromophil, a substance found in the body of a nerve cell, which can result from cell exhaustion or damage to peripheral processes. Axonal damage can lead to various physical or biochemical changes in the neuronal cell body. Cytoskeleton alterations are the main cellular reaction to chromatolysis. Based on their location within the brain, some neurons appear to be more susceptible to peripheral chromatolysis.

Causes
Axotomy (severe damage to axon) Lithium Poisoning Acrylamide Intoxication

Types
Central Chromatolysis Peripheral Chromatolysis

Chemical Mechanisms
Nissl bodies Chromophil

Disease
Fetal Alcohol Syndrome Alzheimer’s ALS Prick’s Disease Corticobasal Degeneration