User:Rockpocket/Git2

ARF GTPase-activating protein GIT2 is an enzyme that in humans is encoded by the GIT2 gene.

This gene encodes a member of the GIT protein family. GIT proteins interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. This gene undergoes extensive alternative splicing; although ten transcript variants have been described, the full length sequence has been determined for only four variants. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding.

Animal models
Model organisms have been used in the study of GIT2 function. A conditional knockout mouse line, called Git2Gt(XG510)Byg, was analysed at the Wellcome Trust Sanger Institute as part of a large scale phenotypic screen.

Mice lacking Git2 had no significant defects in viability or fertility, so further tests were carried out and four significant phenotypes were reported:


 * Mutant mice had differences in their clinical blood chemistry compared to wildtype control mice.
 * Mutant male mice had a decrease in white blood cell count.
 * An increased thickness in hippocampus was observed.
 * Mutant female mice were slower to respond to heat.

Interactions
GIT2 has been shown to interact with GIT1.