User:Rockpocket/MGP/ARHGAP18

Model organisms
Model organisms have been used in the study of ARHGAP18 function. A conditional knockout mouse line, called Arhgap18tm1a(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty three tests were carried out on mutant mice and one significant abnormality was observed. Fewer than expected homozygous mutant embryos were identified during gestation.