User:Rockpocket/MGP/CAPZB

Model organisms
Model organisms have been used in the study of CAPZB function. A conditional knockout mouse line, called Capzbtm1a(EUCOMM)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty three tests were carried out on mutant mice and four significant abnormalities were observed. No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice and decreased circulating triglyceride levels were observed in female animals, while males displayed abnormal behaviour in an open field.