User:Rockpocket/MGP/COG2

Model organisms
Model organisms have been used in the study of COG2 function. A conditional knockout mouse line, called Cog2tm1a(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty five were carried out on mutant mice and one significant abnormality was observed: no homozygous mutant mice survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; no additional significant abnormalities were observed in these animals.