User:Rockpocket/MGP/D11WSU99E

Model organisms
Model organisms have been used in the study of D11Wsu99e function. A conditional knockout mouse line, called D11Wsu99etm2a(EUCOMM)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.

Twenty four tests were carried out on mutant mice, and a significant abnormality was observed in male homozygote's peripheral blood lymphocytes. Specifically, they displayed a decreased B cell number and a corresponding increase in granulocyte number.