User:Rockpocket/MGP/FTO

Model organisms
Model organisms have been used in the study of FTO function. A conditional knockout mouse line, called Ftotm1a(EUCOMM)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty five tests were carried out on mutant mice and only significant skeletal abnormalities were observed including kyphosis and abnormal vertebral transverse processes, and only female homozygous mutant animals.