User:Rockpocket/MGP/GIF

Model organisms
Model organisms have been used in the study of GIF function. A conditional knockout mouse line, called Giftm1a(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty seven tests were carried out on mutant mice and four significant abnormalities were observed. Homozygous mutant males displayed increased aggression towards their pups and therefore had reduced fecundity, mutants of both sex had increased susceptibility to infection with both Citrobacter and Salmonella.