User:Rockpocket/MGP/PRMT7

Model organisms
Model organisms have been used in the study of PRMT7 function. A conditional knockout mouse line, called Prmt7tm1a(EUCOMM)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty five tests were carried out on mutant mice and two significant abnormalities were observed. Fewer than expected homozygous mutant mice survived until weaning and those that did survive displayed evidence of chomosomal instability in a micronucleus test.