User:Rockpocket/MGP/RHOBTB3

Model organisms
Model organisms have been used in the study of RHOBTB3 function. A conditional knockout mouse line, called Rhobtb3tm1a(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty three tests were carried out on mutant mice and four significant abnormalities were observed. Homozygote mutant males had a decreased body weight and abnormal tooth morphology; females had decreased forepaw grip strength and both sexes had a decreased body length.