User:Rockpocket/MGP/SIRT2

Model organisms
Model organisms have been used in the study of SIRT2 function. A conditional knockout mouse line, called Sirt2tm1a(EUCOMM)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.

Twenty five tests were carried out on homozygous mutant adult mice, however no significant abnormalities were observed.