User:Rockpocket/MGP/SRC

Model organisms
Model organisms have been used in the study of SRC function. A conditional knockout mouse line, called Srctm2a(EUCOMM)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on mutant mice and one significant abnormality was observed. Homozygote mutant animales were found to viable, but lacking teeth. Due to the severity of the homozygous phenotype, the remaining tests were carried out on heterozygous mutant adult mice; no additional significant abnormalities were observed in these animals.