User:Rockpocket/MGP/TPD52L2

Model organisms
Model organisms have been used in the study of TPD52L2 function. A conditional knockout mouse line, called Tpd52l2tm1a(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.

Twenty two tests were carried out on mutant mice and one significant abnormality was observed: homozygous adult females displayed a decrease in body length by DEXA.