User:Rockpocket/MGP/TRAF3IP3

Model organisms
Model organisms have been used in the study of TRAF3IP3 function. A conditional knockout mouse line, called Traf3ip3tm1a(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty three tests were carried out on homozygous mutant mice and two significant abnormalities were observed. Males had a decrease in white blood cell count and females had an increased susceptibility to bacterial infection.