User:Romain Cazé, PhD/sandbox

The nystagmus disappeared

Interaction between Depakote™ and Tecfidera™
In June 2016, because of mood disorders, the MSer was prescribed 500mg daily of Depakote ™ (250mg morning, 250mg evening). At the beginning he took it alongside his TecfideraTM treatment.

He then started to observe the first interaction between these medecines. The blushing became more intense and appeared concomittantly with nausea, that is one of the most frequent side effect of Depakote.

With time the interaction became stronger than initially. He diminish to one pill of Tecfidera per Day but immediatly blush after his Depakote. This drug is a strong mood regulator. This seems to suggest that blushing depends on the patient mood.

Nausea is one of the frequent side effect of Depakote™. For this reason starting at 250mg a Day and ramping up to 500mg seems to be the best course of action.

Because of the interaction between Tecifidera™, Depakote™ the side effect have to be carefully monitored, but this combination might be a good treatment against multiple sclerosis.

=An hypothesis= People with Multiple Sclerosis are often highly qualified (citation needed). This suggest a bold hypothesis. MS is not an auto-immune disease. The classic dogma is that the immune system attacks the myelin sheath protecting the axon leaving a scar that can be observed with MRI. There will a scar also if you cut your finger with a knife.

One can propose that action potentials represent en energitical burden for the axon. This burdens might damage the myelin sheath that is repaired by the immune système. So the scar is not due to the immune system.

Valproic acid could act by slowing down neurological activité. Therefore it diminishes the burden on the axon. And hence helps to alleviate the symptoms of MS.